Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401

Ten new diterpene glycosides virescenosides Z(9)-Z(18) (1–10) together with three known analogues (11–13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with t...

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Detalles Bibliográficos
Autores principales: Zhuravleva, Olesya I., Antonov, Alexandr S., Oleinikova, Galina K., Khudyakova, Yuliya V., Popov, Roman S., Denisenko, Vladimir A., Pislyagin, Evgeny A., Chingizova, Ekaterina A., Afiyatullov, Shamil Sh.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891331/
https://www.ncbi.nlm.nih.gov/pubmed/31671910
http://dx.doi.org/10.3390/md17110616
Descripción
Sumario:Ten new diterpene glycosides virescenosides Z(9)-Z(18) (1–10) together with three known analogues (11–13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15–18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated.

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