Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401

Ten new diterpene glycosides virescenosides Z(9)-Z(18) (1–10) together with three known analogues (11–13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with t...

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Autores principales: Zhuravleva, Olesya I., Antonov, Alexandr S., Oleinikova, Galina K., Khudyakova, Yuliya V., Popov, Roman S., Denisenko, Vladimir A., Pislyagin, Evgeny A., Chingizova, Ekaterina A., Afiyatullov, Shamil Sh.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891331/
https://www.ncbi.nlm.nih.gov/pubmed/31671910
http://dx.doi.org/10.3390/md17110616
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author Zhuravleva, Olesya I.
Antonov, Alexandr S.
Oleinikova, Galina K.
Khudyakova, Yuliya V.
Popov, Roman S.
Denisenko, Vladimir A.
Pislyagin, Evgeny A.
Chingizova, Ekaterina A.
Afiyatullov, Shamil Sh.
author_facet Zhuravleva, Olesya I.
Antonov, Alexandr S.
Oleinikova, Galina K.
Khudyakova, Yuliya V.
Popov, Roman S.
Denisenko, Vladimir A.
Pislyagin, Evgeny A.
Chingizova, Ekaterina A.
Afiyatullov, Shamil Sh.
author_sort Zhuravleva, Olesya I.
collection PubMed
description Ten new diterpene glycosides virescenosides Z(9)-Z(18) (1–10) together with three known analogues (11–13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15–18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated.
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spelling pubmed-68913312019-12-12 Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401 Zhuravleva, Olesya I. Antonov, Alexandr S. Oleinikova, Galina K. Khudyakova, Yuliya V. Popov, Roman S. Denisenko, Vladimir A. Pislyagin, Evgeny A. Chingizova, Ekaterina A. Afiyatullov, Shamil Sh. Mar Drugs Article Ten new diterpene glycosides virescenosides Z(9)-Z(18) (1–10) together with three known analogues (11–13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15–18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated. MDPI 2019-10-29 /pmc/articles/PMC6891331/ /pubmed/31671910 http://dx.doi.org/10.3390/md17110616 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhuravleva, Olesya I.
Antonov, Alexandr S.
Oleinikova, Galina K.
Khudyakova, Yuliya V.
Popov, Roman S.
Denisenko, Vladimir A.
Pislyagin, Evgeny A.
Chingizova, Ekaterina A.
Afiyatullov, Shamil Sh.
Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
title Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
title_full Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
title_fullStr Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
title_full_unstemmed Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
title_short Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
title_sort virescenosides from the holothurian-associated fungus acremonium striatisporum kmm 4401
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891331/
https://www.ncbi.nlm.nih.gov/pubmed/31671910
http://dx.doi.org/10.3390/md17110616
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