Spirocyclic Motifs in Natural Products

Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with uni...

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Detalles Bibliográficos
Autores principales: Chupakhin, Evgeny, Babich, Olga, Prosekov, Alexander, Asyakina, Lyudmila, Krasavin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891393/
https://www.ncbi.nlm.nih.gov/pubmed/31744211
http://dx.doi.org/10.3390/molecules24224165
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author Chupakhin, Evgeny
Babich, Olga
Prosekov, Alexander
Asyakina, Lyudmila
Krasavin, Mikhail
author_facet Chupakhin, Evgeny
Babich, Olga
Prosekov, Alexander
Asyakina, Lyudmila
Krasavin, Mikhail
author_sort Chupakhin, Evgeny
collection PubMed
description Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with unique compounds reported in the literature has been undertaken. This review aims to fill that void and analyze the diversity of structurally unique natural products containing spirocyclic moieties of various sizes.
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spelling pubmed-68913932019-12-12 Spirocyclic Motifs in Natural Products Chupakhin, Evgeny Babich, Olga Prosekov, Alexander Asyakina, Lyudmila Krasavin, Mikhail Molecules Review Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with unique compounds reported in the literature has been undertaken. This review aims to fill that void and analyze the diversity of structurally unique natural products containing spirocyclic moieties of various sizes. MDPI 2019-11-17 /pmc/articles/PMC6891393/ /pubmed/31744211 http://dx.doi.org/10.3390/molecules24224165 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chupakhin, Evgeny
Babich, Olga
Prosekov, Alexander
Asyakina, Lyudmila
Krasavin, Mikhail
Spirocyclic Motifs in Natural Products
title Spirocyclic Motifs in Natural Products
title_full Spirocyclic Motifs in Natural Products
title_fullStr Spirocyclic Motifs in Natural Products
title_full_unstemmed Spirocyclic Motifs in Natural Products
title_short Spirocyclic Motifs in Natural Products
title_sort spirocyclic motifs in natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891393/
https://www.ncbi.nlm.nih.gov/pubmed/31744211
http://dx.doi.org/10.3390/molecules24224165
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AT krasavinmikhail spirocyclicmotifsinnaturalproducts

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