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Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes

Prussian blue (PB) is known for its multiple applications ranging from fine arts to therapeutics. More recently, PB nanoparticles have been pointed to as appealing photothermal agents (PA) when irradiated with wavelengths corresponding to the biological windows, namely regions located in the near in...

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Autores principales: Busquets, Maria Antònia, Novella-Xicoy, Ariadna, Guzmán, Valeria, Estelrich, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891449/
https://www.ncbi.nlm.nih.gov/pubmed/31731679
http://dx.doi.org/10.3390/molecules24224137
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author Busquets, Maria Antònia
Novella-Xicoy, Ariadna
Guzmán, Valeria
Estelrich, Joan
author_facet Busquets, Maria Antònia
Novella-Xicoy, Ariadna
Guzmán, Valeria
Estelrich, Joan
author_sort Busquets, Maria Antònia
collection PubMed
description Prussian blue (PB) is known for its multiple applications ranging from fine arts to therapeutics. More recently, PB nanoparticles have been pointed to as appealing photothermal agents (PA) when irradiated with wavelengths corresponding to the biological windows, namely regions located in the near infrared (NIR) zone. In addition, the combination of PB with other components such as phospholipids boosts their therapeutical potential by facilitating, for instance, the incorporation of drugs becoming suitable drug delivery systems. The novelty of the research relies on the synthesis procedure and characterization of hybrid lipid–PB nanoparticles with a high yield in a friendly environment suitable for photothermal therapy. This goal was achieved by first obtaining insoluble PB coated with oleylamine (OA) to facilitate its combination with lipids. The resulting lipid–PB complex showed a monomodal distribution of sizes with an overall size of around 100 nm and a polydispersity index of about 0.200. It highlights one critical step in the synthesis procedure that is the shaking time of the mixture of PB–OA nanoparticles with the lipid, which was found to be 48 h. This time assured homogeneous preparation without the need of further separation stages. Samples were stable for more than three months under several storage conditions.
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spelling pubmed-68914492019-12-18 Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes Busquets, Maria Antònia Novella-Xicoy, Ariadna Guzmán, Valeria Estelrich, Joan Molecules Article Prussian blue (PB) is known for its multiple applications ranging from fine arts to therapeutics. More recently, PB nanoparticles have been pointed to as appealing photothermal agents (PA) when irradiated with wavelengths corresponding to the biological windows, namely regions located in the near infrared (NIR) zone. In addition, the combination of PB with other components such as phospholipids boosts their therapeutical potential by facilitating, for instance, the incorporation of drugs becoming suitable drug delivery systems. The novelty of the research relies on the synthesis procedure and characterization of hybrid lipid–PB nanoparticles with a high yield in a friendly environment suitable for photothermal therapy. This goal was achieved by first obtaining insoluble PB coated with oleylamine (OA) to facilitate its combination with lipids. The resulting lipid–PB complex showed a monomodal distribution of sizes with an overall size of around 100 nm and a polydispersity index of about 0.200. It highlights one critical step in the synthesis procedure that is the shaking time of the mixture of PB–OA nanoparticles with the lipid, which was found to be 48 h. This time assured homogeneous preparation without the need of further separation stages. Samples were stable for more than three months under several storage conditions. MDPI 2019-11-15 /pmc/articles/PMC6891449/ /pubmed/31731679 http://dx.doi.org/10.3390/molecules24224137 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Busquets, Maria Antònia
Novella-Xicoy, Ariadna
Guzmán, Valeria
Estelrich, Joan
Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes
title Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes
title_full Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes
title_fullStr Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes
title_full_unstemmed Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes
title_short Facile Synthesis of Novel Prussian Blue–Lipid Nanocomplexes
title_sort facile synthesis of novel prussian blue–lipid nanocomplexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891449/
https://www.ncbi.nlm.nih.gov/pubmed/31731679
http://dx.doi.org/10.3390/molecules24224137
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