Cargando…

Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome

Prostaglandins and inhibitors of their synthesis (cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs) were shown to play a significant role in the regulation of hematopoiesis. Partly due to their hematopoiesis-modulating effects, both prostaglandins and COX inhibitors were report...

Descripción completa

Detalles Bibliográficos
Autores principales: Hofer, Michal, Hoferová, Zuzana, Falk, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891503/
https://www.ncbi.nlm.nih.gov/pubmed/31698831
http://dx.doi.org/10.3390/molecules24224019
_version_ 1783475829384151040
author Hofer, Michal
Hoferová, Zuzana
Falk, Martin
author_facet Hofer, Michal
Hoferová, Zuzana
Falk, Martin
author_sort Hofer, Michal
collection PubMed
description Prostaglandins and inhibitors of their synthesis (cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs) were shown to play a significant role in the regulation of hematopoiesis. Partly due to their hematopoiesis-modulating effects, both prostaglandins and COX inhibitors were reported to act positively in radiation-exposed mammalian organisms at various pre- and post-irradiation therapeutical settings. Experimental efforts were targeted at finding pharmacological procedures leading to optimization of therapeutical outcomes by minimizing undesirable side effects of the treatments. Progress in these efforts was obtained after discovery of selective inhibitors of inducible selective cyclooxygenase-2 (COX-2) inhibitors. Recent studies have been able to suggest the possibility to find combined therapeutical approaches utilizing joint administration of prostaglandins and inhibitors of their synthesis at optimized timing and dosing of the drugs which could be incorporated into the therapy of patients with acute radiation syndrome.
format Online
Article
Text
id pubmed-6891503
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-68915032019-12-18 Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome Hofer, Michal Hoferová, Zuzana Falk, Martin Molecules Review Prostaglandins and inhibitors of their synthesis (cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs) were shown to play a significant role in the regulation of hematopoiesis. Partly due to their hematopoiesis-modulating effects, both prostaglandins and COX inhibitors were reported to act positively in radiation-exposed mammalian organisms at various pre- and post-irradiation therapeutical settings. Experimental efforts were targeted at finding pharmacological procedures leading to optimization of therapeutical outcomes by minimizing undesirable side effects of the treatments. Progress in these efforts was obtained after discovery of selective inhibitors of inducible selective cyclooxygenase-2 (COX-2) inhibitors. Recent studies have been able to suggest the possibility to find combined therapeutical approaches utilizing joint administration of prostaglandins and inhibitors of their synthesis at optimized timing and dosing of the drugs which could be incorporated into the therapy of patients with acute radiation syndrome. MDPI 2019-11-06 /pmc/articles/PMC6891503/ /pubmed/31698831 http://dx.doi.org/10.3390/molecules24224019 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hofer, Michal
Hoferová, Zuzana
Falk, Martin
Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
title Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
title_full Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
title_fullStr Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
title_full_unstemmed Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
title_short Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
title_sort brief story on prostaglandins, inhibitors of their synthesis, hematopoiesis, and acute radiation syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891503/
https://www.ncbi.nlm.nih.gov/pubmed/31698831
http://dx.doi.org/10.3390/molecules24224019
work_keys_str_mv AT hofermichal briefstoryonprostaglandinsinhibitorsoftheirsynthesishematopoiesisandacuteradiationsyndrome
AT hoferovazuzana briefstoryonprostaglandinsinhibitorsoftheirsynthesishematopoiesisandacuteradiationsyndrome
AT falkmartin briefstoryonprostaglandinsinhibitorsoftheirsynthesishematopoiesisandacuteradiationsyndrome