Cargando…

Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression

Background: Curcumin has been shown to exert pleiotropic biological effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakamae, Ikuko, Morimoto, Tsumoru, Shima, Hiroki, Shionyu, Masafumi, Fujiki, Hisayo, Yoneda-Kato, Noriko, Yokoyama, Takashi, Kanaya, Shigehiko, Kakiuchi, Kiyomi, Shirai, Tsuyoshi, Meiyanto, Edy, Kato, Jun-ya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891586/ https://www.ncbi.nlm.nih.gov/pubmed/31717651 http://dx.doi.org/10.3390/molecules24224067

Ejemplares similares

Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence
por: Lestari, Beni, et al.
Publicado: (2019)

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth
por: Larasati, Yonika Arum, et al.
Publicado: (2018)

Anti-proliferative and Anti-metastatic Potential of Curcumin Analogue, Pentagamavunon-1 (PGV-1), Toward Highly Metastatic Breast Cancer Cells in Correlation with ROS Generation
por: Meiyanto, Edy, et al.
Publicado: (2019)

Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins
por: Hijikata, Atsushi, et al.
Publicado: (2021)

Preclinical evaluation of pentagamavunone-1 as monotherapy and combination therapy for pancreatic cancer in multiple xenograft models
por: Kamitani, Naoki, et al.
Publicado: (2022)

Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2
por: Hijikata, Atsushi, et al.
Publicado: (2021)

Quantitative Photodeprotection Assessment of Caged Resveratrol by Fluorescence Measurement
por: Hikage, Shin, et al.
Publicado: (2017)

Diastereoselective [2+2] Photocycloaddition of Chiral Cyclic Enones with Olefins in Aqueous Media Using Surfactants
por: Nishiyama, Yasuhiro, et al.
Publicado: (2013)

Chemoprevention curcumin analog 1.1 promotes metaphase arrest and enhances intracellular reactive oxygen species levels on TNBC MDA-MB-231 and HER2-positive HCC1954 cells
por: Novitasari, Dhania, et al.
Publicado: (2023)

CCA-1.1, a Novel Curcumin Analog, Exerts Cytotoxic anti-Migratory Activity toward TNBC and HER2-Enriched Breast Cancer Cells
por: Novitasari, Dhania, et al.
Publicado: (2021)

Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs
por: Kukita, Yoji, et al.
Publicado: (2016)

The Target Differences of Anti-Tumorigenesis Potential of Curcumin and its Analogues Against HER-2 Positive and Triple-Negative Breast Cancer Cells
por: Meiyanto, Edy, et al.
Publicado: (2021)

Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties
por: Utomo, Rohmad Yudi, et al.
Publicado: (2022)

Decoding disease-causing mechanisms of missense mutations from supramolecular structures
por: Hijikata, Atsushi, et al.
Publicado: (2017)

Curcumin Analog Pentagamavunon-1 (PGV-1) Sensitizes Widr Cells to 5-Fluorouracil through Inhibition of NF-κB Activation
por: Meiyanto, Edy, et al.
Publicado: (2018)

Cell Cycle Modulation of CHO-K1 Cells Under Genistein Treatment Correlates with Cells Senescence, Apoptosis and ROS Level but in a Dose-Dependent Manner
por: Jenie, Riris Istighfari, et al.
Publicado: (2019)

The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer
por: Meiyanto, Edy, et al.
Publicado: (2019)

Anticancer evaluation of N-benzoyl-3-allylthiourea as potential antibreast cancer agent through enhances HER-2 expression
por: Widiandani, Tri, et al.
Publicado: (2020)

(13)C CPMAS NMR as an Alternative Method to Verify the Quality of Dietary Supplements Containing Curcumin
por: Siudem, Paweł, et al.
Publicado: (2023)

Novel curcumin derivatives as potent inhibitors of amyloid β aggregation
por: Yanagisawa, Daijiro, et al.
Publicado: (2015)

Effects of high-absorption curcumin for the prevention of hypertensive heart disease: a double-blind, placebo-controlled, randomized clinical study
por: Funamoto, Masafumi, et al.
Publicado: (2022)

CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner
por: Yoshida, Akihiro, et al.
Publicado: (2013)

AS-EAST: a functional annotation tool for putative proteins encoded by alternatively spliced transcripts
por: Shionyu, Masafumi, et al.
Publicado: (2012)

Keypunching and verifying
por: Farina, Mario V.
Publicado: (1973)

To trust? Or to verify?
por: Harendza, Sigrid
Publicado: (2018)

Verifiable biology
por: Konur, Savas, et al.
Publicado: (2023)

AMDORAP: Non-targeted metabolic profiling based on high-resolution LC-MS
por: Takahashi, Hiroki, et al.
Publicado: (2011)

Verifiability on the run: an experimental study on the verifiability approach to malingered symptoms
por: Boskovic, Irena, et al.
Publicado: (2018)

Primary success of electrical cardioversion for new-onset atrial fibrillation and its association with clinical course in non-cardiac critically ill patients: sub-analysis of a multicenter observational study
por: Shima, Nozomu, et al.
Publicado: (2021)

Towards verified systems
por: Bowen, J
Publicado: (2013)

Verified Approximation Algorithms
por: Eßmann, Robin, et al.
Publicado: (2020)

Verified Software Units
por: Beringer, Lennart
Publicado: (2021)

Verifying Negative Sentences
por: Wang, Shenshen, et al.
Publicado: (2021)

Verified Provings of Oxygen
por: Swan, S.
Publicado: (1890)

Phase-space monitor system
por: Shintake, Tsumoru
Publicado: (1990)

Beam dynamics in RF-gun semi-analytical approach (longitudinal motion)
por: Shintake, Tsumoru
Publicado: (1991)

Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus
por: Funamoto, Masafumi, et al.
Publicado: (2019)

The Role of the Prod1 Membrane Anchor in Newt Limb Regeneration
por: Nomura, Kaoru, et al.
Publicado: (2016)

Two Active Compounds from Caesalpinia sappan L. in Combination with Cisplatin Synergistically Induce Apoptosis and Cell Cycle Arrest on WiDr Cells
por: Handayani, Sri, et al.
Publicado: (2017)

RESOPS: A Database for Analyzing the Correspondence of RNA Editing Sites to Protein Three-Dimensional Structures
por: Yura, Kei, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_1ass8h2smu7um13o91cgp6ga4h