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Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo
N-Alkylation and N-acylation of the prostaglandin-F(2α) allosteric modulator l-PDC31 were performed to install various alkyl, PEG and isoprenoid groups onto the l-enantiomer of the peptide. Among the different bio-conjugates studied, the N-dodecyl analog reduced prostaglandin-F(2α)-induced mouse myo...
Autores principales: | Poupart, Julien, Hou, Xin, Chemtob, Sylvain, Lubell, William D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891598/ https://www.ncbi.nlm.nih.gov/pubmed/31731725 http://dx.doi.org/10.3390/molecules24224141 |
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