Cargando…

Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications

Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jubete, Guillem, Puig de la Bellacasa, Raimon, Estrada-Tejedor, Roger, Teixidó, Jordi, Borrell, José I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891647/ https://www.ncbi.nlm.nih.gov/pubmed/31744155 http://dx.doi.org/10.3390/molecules24224161

Ejemplares similares

Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70
por: Masip, Victor, et al.
Publicado: (2021)

1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications
por: Oliveras, Juan Marcos, et al.
Publicado: (2021)

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
por: Donaire-Arias, Ana, et al.
Publicado: (2022)

In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models
por: González, Àlex L., et al.
Publicado: (2017)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

6-(2,6-Dimethylphenyl)pyrido[2,3-d]pyrimidin-7-amine
por: Nukui, Seiji, et al.
Publicado: (2009)

Spiro[cyclopentane-1,2′(1′H)-pyrido[2,3-d]pyrimidin]-4′(3′H)-one
por: Shi, Daxin, et al.
Publicado: (2010)

Hexafluoroisopropyl alcohol mediated synthesis of 2,3-dihydro-4H-pyrido[1,2-a]pyrimidin-4-ones
por: Alam, Mohammad A., et al.
Publicado: (2016)

On the Applicability of Elastic Network Models for the Study of RNA CUG Trinucleotide Repeat Overexpansion
por: González, Àlex L., et al.
Publicado: (2016)

Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery
por: Manen-Freixa, Leticia, et al.
Publicado: (2022)

Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines
por: Veselovská, Lucia, et al.
Publicado: (2020)

Design and Synthesis of a Series of Pyrido[2,3-d]pyrimidine Derivatives as CCR4 Antagonists
por: Gong, Hongwei, et al.
Publicado: (2012)

Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
por: Shi, Jianwei, et al.
Publicado: (2023)

6′-Bromo-1′H-spiro[cyclohexane-1,2′-pyrido[2,3-d]pyrimidin]-4′(3′H)-one
por: Yang, Liupan, et al.
Publicado: (2011)

Synthesis, Herbicidal Activity, Mode of Action, and In Silico Analysis of Novel Pyrido[2,3-d]pyrimidine Compounds
por: Min, Lijing, et al.
Publicado: (2023)

Crystal structure of (E)-9-(4-nitrobenzylidene)-8,9-dihydropyrido[2,3-d]pyrrolo[1,2-a]pyrimidin-5(7H)-one
por: Khodjaniyazov, Khamid U., et al.
Publicado: (2016)

Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFR(L858R/T790M) inhibitors
por: Fu, Jianfang, et al.
Publicado: (2023)

Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold
por: Elzahabi, Heba S. A., et al.
Publicado: (2018)

Cognate RNA-Binding Modes by the Alternative-Splicing Regulator MBNL1 Inferred from Molecular Dynamics
por: González, Àlex L., et al.
Publicado: (2022)

Poly[bis[8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylato]cadmium]
por: Gao, Jun, et al.
Publicado: (2010)

Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II
por: Kuday, Hilal, et al.
Publicado: (2014)

Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives
por: El-Kalyoubi, Samar, et al.
Publicado: (2020)

Syntheses and Cell-Based Phenotypic Screen of Novel 7-Amino pyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives as Potential Antiproliferative Agents
por: Yang, Tao, et al.
Publicado: (2012)

3-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
por: Jasinski, Jerry P., et al.
Publicado: (2009)

7-Benzyl-3-(4-fluorophenyl)-2-propylamino-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one
por: Hu, Hai-Jun, et al.
Publicado: (2012)

7-Benzyl-3-(4-chlorophenyl)-2-isobutylamino-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one
por: Chen, Hong, et al.
Publicado: (2012)

7-Benzyl-2-[(cyclopropylmethyl)amino]-3-phenyl-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one
por: Chen, Hong
Publicado: (2011)

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
por: El-Kashef, Hussein, et al.
Publicado: (2010)

A facile and concise route to (hydroxybenzoyl)pyrido[2,3-d]pyrimidine heterocycle derivatives: synthesis, and structural, spectral and computational exploration
por: Ashraf, Abida, et al.
Publicado: (2019)

Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
por: Ghosh, Prasanjit, et al.
Publicado: (2021)

Poly[bis[μ(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylato]nickel(II)]
por: An, Zhe, et al.
Publicado: (2010)

Aquabis(2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-olato)nickel(II)
por: Zhang, Huaihong, et al.
Publicado: (2009)

Synthesis of Some Spiro Indeno[1,2-b]pyrido[2,3-d]Pyrimidine-5,3′-Indolines as New Urease Inhibitors
por: Mohammadi Ziarani, Ghodsi, et al.
Publicado: (2016)

Synthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl]-3H-pyrido[2,3-d]pyrimidin-4-one derivatives
por: Rahmani Khajouei, Marzieh, et al.
Publicado: (2021)

7-Benzyl-3-(4-fluorophenyl)-2-(pyrrolidin-1-yl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one
por: Chen, Hong, et al.
Publicado: (2011)

Poly[[bis[μ(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylato]manganese(II)] dihydrate]
por: Huang, Jing, et al.
Publicado: (2008)

Poly[[bis[μ(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylato]cobalt(II)] dihydrate]
por: Qi, Xu, et al.
Publicado: (2009)

Poly[[bis[μ(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylato]zinc(II)] dihydrate]
por: Xu, Wen, et al.
Publicado: (2009)

Crystal structures of 2,3-bis(thiophen-2-yl)pyrido[2,3-b]pyrazine and 7-bromo-2,3-bis(thiophen-2-yl)pyrido[2,3-b]pyrazine
por: Popek, Rafal, et al.
Publicado: (2019)

Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers
por: Elzahabi, Heba S. A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tn5nej75n3fac34m96rkpeeg36