Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime

We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in m...

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Detalles Bibliográficos
Autores principales: Yuan, Chunling, Zhang, Lei, Zhao, Yingdai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891672/
https://www.ncbi.nlm.nih.gov/pubmed/31752140
http://dx.doi.org/10.3390/molecules24224177
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author Yuan, Chunling
Zhang, Lei
Zhao, Yingdai
author_facet Yuan, Chunling
Zhang, Lei
Zhao, Yingdai
author_sort Yuan, Chunling
collection PubMed
description We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaffolds found in FDA-approved pharmaceuticals.
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spelling pubmed-68916722019-12-12 Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime Yuan, Chunling Zhang, Lei Zhao, Yingdai Molecules Article We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaffolds found in FDA-approved pharmaceuticals. MDPI 2019-11-18 /pmc/articles/PMC6891672/ /pubmed/31752140 http://dx.doi.org/10.3390/molecules24224177 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Chunling
Zhang, Lei
Zhao, Yingdai
Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime
title Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime
title_full Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime
title_fullStr Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime
title_full_unstemmed Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime
title_short Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and N-Nucleophiles Promoted by α-Benzoin Oxime
title_sort cu(ii)-catalyzed c-n coupling of (hetero)aryl halides and n-nucleophiles promoted by α-benzoin oxime
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891672/
https://www.ncbi.nlm.nih.gov/pubmed/31752140
http://dx.doi.org/10.3390/molecules24224177
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