Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction

New catalysts for important C–N bond formation are highly sought after. In this work, we demonstrate the synthesis and viability of a new class of planar chiral [2.2]paracyclophane-based bisoxazoline (BOX) ligands for the copper-catalyzed N–H insertion of α-diazocarbonyls into anilines. The reaction...

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Detalles Bibliográficos
Autores principales: Knoll, Daniel M., Hu, Yuling, Hassan, Zahid, Nieger, Martin, Bräse, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891757/
https://www.ncbi.nlm.nih.gov/pubmed/31739572
http://dx.doi.org/10.3390/molecules24224122
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author Knoll, Daniel M.
Hu, Yuling
Hassan, Zahid
Nieger, Martin
Bräse, Stefan
author_facet Knoll, Daniel M.
Hu, Yuling
Hassan, Zahid
Nieger, Martin
Bräse, Stefan
author_sort Knoll, Daniel M.
collection PubMed
description New catalysts for important C–N bond formation are highly sought after. In this work, we demonstrate the synthesis and viability of a new class of planar chiral [2.2]paracyclophane-based bisoxazoline (BOX) ligands for the copper-catalyzed N–H insertion of α-diazocarbonyls into anilines. The reaction features a wide substrate scope and moderate to excellent yields, and delivers the valuable products at ambient conditions.
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spelling pubmed-68917572019-12-12 Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction Knoll, Daniel M. Hu, Yuling Hassan, Zahid Nieger, Martin Bräse, Stefan Molecules Communication New catalysts for important C–N bond formation are highly sought after. In this work, we demonstrate the synthesis and viability of a new class of planar chiral [2.2]paracyclophane-based bisoxazoline (BOX) ligands for the copper-catalyzed N–H insertion of α-diazocarbonyls into anilines. The reaction features a wide substrate scope and moderate to excellent yields, and delivers the valuable products at ambient conditions. MDPI 2019-11-14 /pmc/articles/PMC6891757/ /pubmed/31739572 http://dx.doi.org/10.3390/molecules24224122 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Knoll, Daniel M.
Hu, Yuling
Hassan, Zahid
Nieger, Martin
Bräse, Stefan
Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction
title Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction
title_full Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction
title_fullStr Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction
title_full_unstemmed Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction
title_short Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N–H Insertion Reaction
title_sort planar chiral [2.2]paracyclophane-based bisoxazoline ligands and their applications in cu-mediated n–h insertion reaction
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891757/
https://www.ncbi.nlm.nih.gov/pubmed/31739572
http://dx.doi.org/10.3390/molecules24224122
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