Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the...

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Detalles Bibliográficos
Autores principales: Andrud, Kristin, Xing, Hong, Gabrielsen, Bjarne, Bloom, Linda, Mahnir, Vladimir, Lee, Stephen, Green, Benedict T., Lindstrom, Jon, Kem, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891768/
https://www.ncbi.nlm.nih.gov/pubmed/31671780
http://dx.doi.org/10.3390/md17110614

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