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The Dynamics of Hole Transfer in DNA

High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, ki...

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Detalles Bibliográficos
Autores principales: Peluso, Andrea, Caruso, Tonino, Landi, Alessandro, Capobianco, Amedeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891780/
https://www.ncbi.nlm.nih.gov/pubmed/31703470
http://dx.doi.org/10.3390/molecules24224044
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author Peluso, Andrea
Caruso, Tonino
Landi, Alessandro
Capobianco, Amedeo
author_facet Peluso, Andrea
Caruso, Tonino
Landi, Alessandro
Capobianco, Amedeo
author_sort Peluso, Andrea
collection PubMed
description High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, kinetic and chemical aspects of the hole transport in DNA is important not only for its biological consequences, but also for assessing the properties of DNA in redox sensing or labeling. Furthermore, due to hole migration, DNA could potentially play an important role in nanoelectronics, by acting as both a template and active component. Herein, we review our work on the dynamics of hole transfer in DNA carried out in the last decade. After retrieving the thermodynamic parameters needed to address the dynamics of hole transfer by voltammetric and spectroscopic experiments and quantum chemical computations, we develop a theoretical methodology which allows for a faithful interpretation of the kinetics of the hole transport in DNA and is also capable of taking into account sequence-specific effects.
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spelling pubmed-68917802019-12-12 The Dynamics of Hole Transfer in DNA Peluso, Andrea Caruso, Tonino Landi, Alessandro Capobianco, Amedeo Molecules Review High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, kinetic and chemical aspects of the hole transport in DNA is important not only for its biological consequences, but also for assessing the properties of DNA in redox sensing or labeling. Furthermore, due to hole migration, DNA could potentially play an important role in nanoelectronics, by acting as both a template and active component. Herein, we review our work on the dynamics of hole transfer in DNA carried out in the last decade. After retrieving the thermodynamic parameters needed to address the dynamics of hole transfer by voltammetric and spectroscopic experiments and quantum chemical computations, we develop a theoretical methodology which allows for a faithful interpretation of the kinetics of the hole transport in DNA and is also capable of taking into account sequence-specific effects. MDPI 2019-11-07 /pmc/articles/PMC6891780/ /pubmed/31703470 http://dx.doi.org/10.3390/molecules24224044 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peluso, Andrea
Caruso, Tonino
Landi, Alessandro
Capobianco, Amedeo
The Dynamics of Hole Transfer in DNA
title The Dynamics of Hole Transfer in DNA
title_full The Dynamics of Hole Transfer in DNA
title_fullStr The Dynamics of Hole Transfer in DNA
title_full_unstemmed The Dynamics of Hole Transfer in DNA
title_short The Dynamics of Hole Transfer in DNA
title_sort dynamics of hole transfer in dna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891780/
https://www.ncbi.nlm.nih.gov/pubmed/31703470
http://dx.doi.org/10.3390/molecules24224044
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