Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668

Six new carotane sesquiterpenoids piltunines A–F (1–6) together with known compounds (7–9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1–7 were determined based on circular...

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Autores principales: Afiyatullov, Shamil Sh., Zhuravleva, Olesya I., Antonov, Alexandr S., Leshchenko, Elena V., Pivkin, Mikhail V., Khudyakova, Yuliya V., Denisenko, Vladimir A., Pislyagin, Evgeny A., Kim, Natalya Yu., Berdyshev, Dmitrii V., von Amsberg, Gunhild, Dyshlovoy, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891813/
https://www.ncbi.nlm.nih.gov/pubmed/31752168
http://dx.doi.org/10.3390/md17110647
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author Afiyatullov, Shamil Sh.
Zhuravleva, Olesya I.
Antonov, Alexandr S.
Leshchenko, Elena V.
Pivkin, Mikhail V.
Khudyakova, Yuliya V.
Denisenko, Vladimir A.
Pislyagin, Evgeny A.
Kim, Natalya Yu.
Berdyshev, Dmitrii V.
von Amsberg, Gunhild
Dyshlovoy, Sergey A.
author_facet Afiyatullov, Shamil Sh.
Zhuravleva, Olesya I.
Antonov, Alexandr S.
Leshchenko, Elena V.
Pivkin, Mikhail V.
Khudyakova, Yuliya V.
Denisenko, Vladimir A.
Pislyagin, Evgeny A.
Kim, Natalya Yu.
Berdyshev, Dmitrii V.
von Amsberg, Gunhild
Dyshlovoy, Sergey A.
author_sort Afiyatullov, Shamil Sh.
collection PubMed
description Six new carotane sesquiterpenoids piltunines A–F (1–6) together with known compounds (7–9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1–7 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined.
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spelling pubmed-68918132019-12-23 Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668 Afiyatullov, Shamil Sh. Zhuravleva, Olesya I. Antonov, Alexandr S. Leshchenko, Elena V. Pivkin, Mikhail V. Khudyakova, Yuliya V. Denisenko, Vladimir A. Pislyagin, Evgeny A. Kim, Natalya Yu. Berdyshev, Dmitrii V. von Amsberg, Gunhild Dyshlovoy, Sergey A. Mar Drugs Article Six new carotane sesquiterpenoids piltunines A–F (1–6) together with known compounds (7–9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1–7 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined. MDPI 2019-11-18 /pmc/articles/PMC6891813/ /pubmed/31752168 http://dx.doi.org/10.3390/md17110647 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Afiyatullov, Shamil Sh.
Zhuravleva, Olesya I.
Antonov, Alexandr S.
Leshchenko, Elena V.
Pivkin, Mikhail V.
Khudyakova, Yuliya V.
Denisenko, Vladimir A.
Pislyagin, Evgeny A.
Kim, Natalya Yu.
Berdyshev, Dmitrii V.
von Amsberg, Gunhild
Dyshlovoy, Sergey A.
Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
title Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
title_full Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
title_fullStr Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
title_full_unstemmed Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
title_short Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
title_sort piltunines a–f from the marine-derived fungus penicillium piltunense kmm 4668
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891813/
https://www.ncbi.nlm.nih.gov/pubmed/31752168
http://dx.doi.org/10.3390/md17110647
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