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Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China

BACKGROUND: Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frail...

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Autores principales: Ruan, Ye, Guo, Yanfei, Kowal, Paul, Lu, Ye, Liu, Chazhen, Sun, Shuangyuan, Huang, Zhezhou, Zheng, Yang, Wang, Wenjing, Li, Gan, Shi, Yan, Wu, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891965/
https://www.ncbi.nlm.nih.gov/pubmed/31796000
http://dx.doi.org/10.1186/s12877-019-1342-5
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author Ruan, Ye
Guo, Yanfei
Kowal, Paul
Lu, Ye
Liu, Chazhen
Sun, Shuangyuan
Huang, Zhezhou
Zheng, Yang
Wang, Wenjing
Li, Gan
Shi, Yan
Wu, Fan
author_facet Ruan, Ye
Guo, Yanfei
Kowal, Paul
Lu, Ye
Liu, Chazhen
Sun, Shuangyuan
Huang, Zhezhou
Zheng, Yang
Wang, Wenjing
Li, Gan
Shi, Yan
Wu, Fan
author_sort Ruan, Ye
collection PubMed
description BACKGROUND: Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China. METHODS: The study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13 g/dL for men and less than 12 g/dL for women. A Frailty Index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model. RESULTS: The prevalence of anemia was 31.0% (95%CI: 28.4, 33.8%) and frailty 14.7% (95%CI: 13.5, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR = 1.62, 95% CI: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR = 1.31, 95% CI:1.09, 1.57). Each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR = 0.96, 95% CI: 0.93, 0.99). CONCLUSION: Anemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty.
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spelling pubmed-68919652019-12-11 Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China Ruan, Ye Guo, Yanfei Kowal, Paul Lu, Ye Liu, Chazhen Sun, Shuangyuan Huang, Zhezhou Zheng, Yang Wang, Wenjing Li, Gan Shi, Yan Wu, Fan BMC Geriatr Research Article BACKGROUND: Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China. METHODS: The study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13 g/dL for men and less than 12 g/dL for women. A Frailty Index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model. RESULTS: The prevalence of anemia was 31.0% (95%CI: 28.4, 33.8%) and frailty 14.7% (95%CI: 13.5, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR = 1.62, 95% CI: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR = 1.31, 95% CI:1.09, 1.57). Each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR = 0.96, 95% CI: 0.93, 0.99). CONCLUSION: Anemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty. BioMed Central 2019-12-04 /pmc/articles/PMC6891965/ /pubmed/31796000 http://dx.doi.org/10.1186/s12877-019-1342-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ruan, Ye
Guo, Yanfei
Kowal, Paul
Lu, Ye
Liu, Chazhen
Sun, Shuangyuan
Huang, Zhezhou
Zheng, Yang
Wang, Wenjing
Li, Gan
Shi, Yan
Wu, Fan
Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
title Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
title_full Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
title_fullStr Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
title_full_unstemmed Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
title_short Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
title_sort association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891965/
https://www.ncbi.nlm.nih.gov/pubmed/31796000
http://dx.doi.org/10.1186/s12877-019-1342-5
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