Cargando…

Potential factors contributing to the poor antimicrobial efficacy of SAAP-148 in a rat wound infection model

BACKGROUND: We investigated the efficacy of a synthetic antimicrobial peptide SAAP-148, which was shown to be effective against Methicillin-resistant Staphylococcus aureus (MRSA) on tape-stripped mice skin. Unexpectedly, SAAP-148 was not effective against MRSA in our pilot study using rats with exci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dijksteel, Gabrielle S., Ulrich, Magda M. W., Vlig, Marcel, Nibbering, Peter H., Cordfunke, Robert A., Drijfhout, Jan W., Middelkoop, Esther, Boekema, Bouke K. H. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891976/ https://www.ncbi.nlm.nih.gov/pubmed/31796055 http://dx.doi.org/10.1186/s12941-019-0336-7

Ejemplares similares

Physical and Functional Characterization of PLGA Nanoparticles Containing the Antimicrobial Peptide SAAP-148
por: Ali, Muhanad, et al.
Publicado: (2023)

SPS-neutralization in tissue samples for efficacy testing of antimicrobial peptides
por: Dijksteel, Gabrielle Sherella, et al.
Publicado: (2019)

Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin
por: van Gent, Miriam E., et al.
Publicado: (2022)

Safety and bactericidal efficacy of cold atmospheric plasma generated by a flexible surface Dielectric Barrier Discharge device against Pseudomonas aeruginosa in vitro and in vivo
por: Dijksteel, Gabrielle S., et al.
Publicado: (2020)

Where Electrostatics Matter: Bacterial Surface Neutralization and Membrane Disruption by Antimicrobial Peptides SAAP-148 and OP-145
por: Vejzovic, Djenana, et al.
Publicado: (2022)

Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs)
por: Dijksteel, Gabrielle S., et al.
Publicado: (2021)

C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities
por: van Gent, Miriam E., et al.
Publicado: (2023)

Membrane Activity of LL-37 Derived Antimicrobial Peptides against Enterococcus hirae: Superiority of SAAP-148 over OP-145
por: Piller, Paulina, et al.
Publicado: (2022)

Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections
por: van Gent, Miriam E., et al.
Publicado: (2023)

Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing
por: Boekema, Bouke, et al.
Publicado: (2021)

Early intervention by Captopril does not improve wound healing of partial thickness burn wounds in a rat model
por: Akershoek, Johanneke J.J., et al.
Publicado: (2018)

Differential effects of Losartan and Atorvastatin in partial and full thickness burn wounds
por: Akershoek, Johanneke J., et al.
Publicado: (2017)

Bactericidal Activity to Escherichia coli: Different Modes of Action of Two 24-Mer Peptides SAAP-148 and OP-145, Both Derived from Human Cathelicidine LL-37
por: Ön, Ayse, et al.
Publicado: (2023)

SAAP-148 Eradicates MRSA Persisters Within Mature Biofilm Models Simulating Prosthetic Joint Infection
por: Scheper, Henk, et al.
Publicado: (2021)

Full Skin Equivalent Models for Simulation of Burn Wound Healing, Exploring Skin Regeneration and Cytokine Response
por: Mulder, Patrick P. G., et al.
Publicado: (2023)

The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations
por: Adélaïde, Morgane, et al.
Publicado: (2023)

Monocytes and T cells incorporated in full skin equivalents to study innate or adaptive immune reactions after burn injury
por: Mulder, Patrick P.G., et al.
Publicado: (2023)

Cell therapy for full-thickness wounds: are fetal dermal cells a potential source?
por: Akershoek, J. J., et al.
Publicado: (2015)

SAAP-RRBS: streamlined analysis and annotation pipeline for reduced representation bisulfite sequencing
por: Sun, Zhifu, et al.
Publicado: (2012)

Antimicrobial Peptides in Biomedical Device Manufacturing
por: Riool, Martijn, et al.
Publicado: (2017)

The SAAP pipeline and database: tools to analyze the impact and predict the pathogenicity of mutations
por: Al-Numair, Nouf S, et al.
Publicado: (2013)

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles
por: Mulder, Patrick P. G., et al.
Publicado: (2021)

Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines
por: Mulder, Patrick P.G., et al.
Publicado: (2022)

Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
por: Marck, Roos E., et al.
Publicado: (2019)

Inflammatory and Antimicrobial Responses to Methicillin-Resistant Staphylococcus aureus in an In Vitro Wound Infection Model
por: Haisma, Elisabeth M., et al.
Publicado: (2013)

Complement Activation and Inhibition in Wound Healing
por: Cazander, Gwendolyn, et al.
Publicado: (2012)

Band structure in /sup 148/Ce from the decay of mass separated /sup 148/La
por: Gill, R L, et al.
Publicado: (1981)

Cardiac Infarction: A Study of 148 Cases
por: Harrington, A. W., et al.
Publicado: (1933)

CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides
por: Bournez, Colin, et al.
Publicado: (2023)

Short- and Long-term Outcomes of an Acellular Dermal Substitute versus Standard of Care in Burns and Reconstructions: A Phase I/II Intrapatient Randomized Controlled Trial
por: Gardien, Kim L. M., et al.
Publicado: (2023)

Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria
por: Lennard, Patrick R., et al.
Publicado: (2023)

Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer
por: Nersisyan, Stepan, et al.
Publicado: (2021)

Comparison between human fetal and adult skin
por: Coolen, Neeltje A., et al.
Publicado: (2009)

Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues
por: Ajdarkosh, Hossein, et al.
Publicado: (2015)

148th SPSC Meeting
Publicado: (2023)

148th LHCC Meeting
Publicado: (2021)

microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression
por: Heo, Mi Jeong, et al.
Publicado: (2014)

Synapse too exclusive for CD148
por: LeBrasseur, Nicole
Publicado: (2003)

Collaboration Agreement No. Kl148/AB
por: The European Organisation for Nuclear Research, CERN, et al.
Publicado: (2005)

Minutes of the 148th Meeting of the LHCC
por: CERN. Geneva. Large Hadron Collider Experiments Committee, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_06lgt5bkppluv0hll2mhm4h5uv