A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

Tau is a microtubule-binding protein that can receive various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. Hyperphosphorylation of tau is linked to its aggregation and the formation of neurofibrilla...

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Detalles Bibliográficos
Autores principales: Ercan-Herbst, Ebru, Ehrig, Jens, Schöndorf, David C., Behrendt, Annika, Klaus, Bernd, Gomez Ramos, Borja, Prat Oriol, Nuria, Weber, Christian, Ehrnhoefer, Dagmar E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892178/
https://www.ncbi.nlm.nih.gov/pubmed/31796124
http://dx.doi.org/10.1186/s40478-019-0823-2

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