Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus()

The global emergence of antibiotic resistance is one of the most serious challenges facing modern medicine. There is an urgent need for validation of new drug targets and the development of small molecules with novel mechanisms of action. We therefore sought to inhibit bacterial DNA repair mediated...

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Detalles Bibliográficos
Autores principales: Lim, Carine S.Q., Ha, Kam Pou, Clarke, Rebecca S., Gavin, Leigh-Anne, Cook, Declan T., Hutton, Jennie A., Sutherell, Charlotte L., Edwards, Andrew M., Evans, Lindsay E., Tate, Edward W., Lanyon-Hogg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892255/
https://www.ncbi.nlm.nih.gov/pubmed/31307763
http://dx.doi.org/10.1016/j.bmc.2019.06.025

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