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The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia

Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to various stimuli including pH, volume, urea, and oxygen tension, an...

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Detalles Bibliográficos
Autores principales:	Lu, David C.-Y., Hannemann, Anke, Wadud, Rasiqh, Rees, David C., Brewin, John N., Low, Philip S., Gibson, John S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Signaling and Cell Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892352/ https://www.ncbi.nlm.nih.gov/pubmed/31729557 http://dx.doi.org/10.1007/s00424-019-02327-7

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