Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity

PURPOSE: We address the hypothesis that uncoupling protein 2 (UCP2), a cellular glucose regulator, delays physiologic retinal vascular development (PRVD) by interfering with glucose uptake through glucose transporter 1 (Glut1). METHODS: In the rat 50/10 oxygen-induced retinopathy (OIR) model, retina...

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Detalles Bibliográficos
Autores principales: Han, Xiaokun, Kong, Jun, Hartnett, M. Elizabeth, Wang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892377/
https://www.ncbi.nlm.nih.gov/pubmed/30995317
http://dx.doi.org/10.1167/iovs.19-26553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892377/
https://www.ncbi.nlm.nih.gov/pubmed/30995317
http://dx.doi.org/10.1167/iovs.19-26553

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