Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization

Epigenetic modifications play critical roles in inducing long-lasting immunological memory in innate immune cells, termed trained immunity. Whether similar epigenetic mechanisms regulate dendtritic cell (DC) function to orchestrate development of adaptive immunity remains unknown. We report that DCs...

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Detalles Bibliográficos
Autores principales: Eastman, Alison J., Xu, Jintao, Bermik, Jennifer, Potchen, Nicole, den Dekker, Aaron, Neal, Lori M., Zhao, Guolei, Malachowski, Antoni, Schaller, Matt, Kunkel, Steven, Osterholzer, John J., Kryczek, Ilona, Olszewski, Michal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892624/
https://www.ncbi.nlm.nih.gov/pubmed/31840058
http://dx.doi.org/10.1126/sciadv.aaw9051

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