Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication

We undertook a functional dissection of chromatin remodeler BAZ1B in neural crest (NC) stem cells (NCSCs) from a uniquely informative cohort of typical and atypical patients harboring 7q11.23 copy number variants. Our results reveal a key contribution of BAZ1B to NCSC in vitro induction and migratio...

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Detalles Bibliográficos
Autores principales: Zanella, Matteo, Vitriolo, Alessandro, Andirko, Alejandro, Martins, Pedro Tiago, Sturm, Stefanie, O’Rourke, Thomas, Laugsch, Magdalena, Malerba, Natascia, Skaros, Adrianos, Trattaro, Sebastiano, Germain, Pierre-Luc, Mihailovic, Marija, Merla, Giuseppe, Rada-Iglesias, Alvaro, Boeckx, Cedric, Testa, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892627/
https://www.ncbi.nlm.nih.gov/pubmed/31840056
http://dx.doi.org/10.1126/sciadv.aaw7908

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