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The Giant Protein Titin’s Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent genetic defects are truncation variants of the titin gene (TTNtv). TTN encodes titin, which is the largest protein i...

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Detalles Bibliográficos
Autores principales:	Tharp, Charles A., Haywood, Mary E., Sbaizero, Orfeo, Taylor, Matthew R. G., Mestroni, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892752/ https://www.ncbi.nlm.nih.gov/pubmed/31849696 http://dx.doi.org/10.3389/fphys.2019.01436

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