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Nanomedicines: A Potential Treatment for Blood Disorder Diseases

Blood disorder diseases (BDDs), also known as hematologic, is one of the diseases owing to hematopoietic system disorder. Chemotherapy, bone marrow transplantation, and stem cells therapy have been used to treat BDDs. However, the cure rates are still low due to the availability of the right type of...

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Detalles Bibliográficos
Autores principales: Zhang, Nan, Wei, Ming-Yuan, Ma, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892756/
https://www.ncbi.nlm.nih.gov/pubmed/31850329
http://dx.doi.org/10.3389/fbioe.2019.00369
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author Zhang, Nan
Wei, Ming-Yuan
Ma, Qiang
author_facet Zhang, Nan
Wei, Ming-Yuan
Ma, Qiang
author_sort Zhang, Nan
collection PubMed
description Blood disorder diseases (BDDs), also known as hematologic, is one of the diseases owing to hematopoietic system disorder. Chemotherapy, bone marrow transplantation, and stem cells therapy have been used to treat BDDs. However, the cure rates are still low due to the availability of the right type of bone marrow and the likelihood of recurrence and infection. With the rapid development of nanotechnology in the field of biomedicine, artificial blood or blood substitute has shown promising features for the emergency treatment of BDDs. Herein, we surveyed recent advances in the development of artificial blood components: gas carrier components (erythrocyte substitutes), immune response components (white blood cell substitutes), and hemostasis-responsive components (platelet substitutes). Platelet-inspired nanomedicines for cancer treatment were also discussed. The challenges and prospects of these treatment options in future nanomedicine development are discussed.
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spelling pubmed-68927562019-12-17 Nanomedicines: A Potential Treatment for Blood Disorder Diseases Zhang, Nan Wei, Ming-Yuan Ma, Qiang Front Bioeng Biotechnol Bioengineering and Biotechnology Blood disorder diseases (BDDs), also known as hematologic, is one of the diseases owing to hematopoietic system disorder. Chemotherapy, bone marrow transplantation, and stem cells therapy have been used to treat BDDs. However, the cure rates are still low due to the availability of the right type of bone marrow and the likelihood of recurrence and infection. With the rapid development of nanotechnology in the field of biomedicine, artificial blood or blood substitute has shown promising features for the emergency treatment of BDDs. Herein, we surveyed recent advances in the development of artificial blood components: gas carrier components (erythrocyte substitutes), immune response components (white blood cell substitutes), and hemostasis-responsive components (platelet substitutes). Platelet-inspired nanomedicines for cancer treatment were also discussed. The challenges and prospects of these treatment options in future nanomedicine development are discussed. Frontiers Media S.A. 2019-11-28 /pmc/articles/PMC6892756/ /pubmed/31850329 http://dx.doi.org/10.3389/fbioe.2019.00369 Text en Copyright © 2019 Zhang, Wei and Ma. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zhang, Nan
Wei, Ming-Yuan
Ma, Qiang
Nanomedicines: A Potential Treatment for Blood Disorder Diseases
title Nanomedicines: A Potential Treatment for Blood Disorder Diseases
title_full Nanomedicines: A Potential Treatment for Blood Disorder Diseases
title_fullStr Nanomedicines: A Potential Treatment for Blood Disorder Diseases
title_full_unstemmed Nanomedicines: A Potential Treatment for Blood Disorder Diseases
title_short Nanomedicines: A Potential Treatment for Blood Disorder Diseases
title_sort nanomedicines: a potential treatment for blood disorder diseases
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892756/
https://www.ncbi.nlm.nih.gov/pubmed/31850329
http://dx.doi.org/10.3389/fbioe.2019.00369
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