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Resistance to BTK inhibition by ibrutinib can be overcome by preventing FOXO3a nuclear export and PI3K/AKT activation in B-cell lymphoid malignancies

Chronic activation of the Bruton’s tyrosine kinase (BTK)-mediated B-cell receptor (BCR) signaling is a hallmark of many B-cell lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL). Ibrutinib, an FDA approved, orally administered BTK inhibitor,...

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Detalles Bibliográficos
Autores principales:	Kapoor, Isha, Li, Yue, Sharma, Arishya, Zhu, Huayuan, Bodo, Juraj, Xu, Wei, Hsi, Eric D., Hill, Brian T., Almasan, Alexandru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892912/ https://www.ncbi.nlm.nih.gov/pubmed/31801949 http://dx.doi.org/10.1038/s41419-019-2158-0

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