Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment

Novel silyl cyanocinnamic acid derivatives have been synthesized and evaluated as potential anticancer agents. In vitro studies reveal that lead derivatives 2a and 2b have enhanced cancer cell proliferation inhibition properties when compared to the parent monocarboxylate transporter (MCT) inhibitor...

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Detalles Bibliográficos
Autores principales: Nelson, Grady L., Ronayne, Conor T., Solano, Lucas N., Jonnalagadda, Sravan K., Jonnalagadda, Shirisha, Rumbley, Jon, Holy, Jon, Rose-Hellekant, Teresa, Drewes, Lester R., Mereddy, Venkatram R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892925/
https://www.ncbi.nlm.nih.gov/pubmed/31797891
http://dx.doi.org/10.1038/s41598-019-54709-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892925/
https://www.ncbi.nlm.nih.gov/pubmed/31797891
http://dx.doi.org/10.1038/s41598-019-54709-7

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