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Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

Bone morphogenetic proteins (BMPs) are secreted ligands of the transforming growth factor-β (TGF-β) family that control embryonic patterning, as well as tissue development and homeostasis. Loss of function mutations in the type II BMP receptor BMPR2 are the leading cause of pulmonary arterial hypert...

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Detalles Bibliográficos
Autores principales:	Chaikuad, Apirat, Thangaratnarajah, Chancievan, von Delft, Frank, Bullock, Alex N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892941/ https://www.ncbi.nlm.nih.gov/pubmed/31797984 http://dx.doi.org/10.1038/s41598-019-54830-7

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