Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein...

Descripción completa

Detalles Bibliográficos
Autores principales: Strohäker, Timo, Jung, Byung Chul, Liou, Shu-Hao, Fernandez, Claudio O., Riedel, Dietmar, Becker, Stefan, Halliday, Glenda M., Bennati, Marina, Kim, Woojin S., Lee, Seung-Jae, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893031/
https://www.ncbi.nlm.nih.gov/pubmed/31797870
http://dx.doi.org/10.1038/s41467-019-13564-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893031/
https://www.ncbi.nlm.nih.gov/pubmed/31797870
http://dx.doi.org/10.1038/s41467-019-13564-w

Ejemplares similares