Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3. To elucidate molecular mechanisms of the condition and identify drug targets, we establish...

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Detalles Bibliográficos
Autores principales: Kelleher, Joseph, Dickinson, Adam, Cain, Stuart, Hu, Yanhua, Bates, Nicola, Harvey, Adam, Ren, Jianzhen, Zhang, Wenjun, Moreton, Fiona C., Muir, Keith W., Ward, Christopher, Touyz, Rhian M., Sharma, Pankaj, Xu, Qingbo, Kimber, Susan J., Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893064/
https://www.ncbi.nlm.nih.gov/pubmed/31680059
http://dx.doi.org/10.1016/j.stemcr.2019.10.004

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