Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells

Class 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely applied for targeting DNA sequences in eukaryotic genomes. However, class I CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature, remain largely unexplored for genome engineering applications. Here, we show...

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Detalles Bibliográficos
Autores principales: Pickar-Oliver, Adrian, Black, Joshua B., Lewis, Mae M., Mutchnick, Kevin J., Klann, Tyler S., Gilcrest, Kylie A., Sitton, Madeleine J., Nelson, Christopher E., Barrera, Alejandro, Bartelt, Luke C., Reddy, Timothy E., Beisel, Chase L., Barrangou, Rodolphe, Gersbach, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893126/
https://www.ncbi.nlm.nih.gov/pubmed/31548729
http://dx.doi.org/10.1038/s41587-019-0235-7

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