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Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior

The recent reclassification of a follicular variant of papillary thyroid carcinoma (FVPTC), subset as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), aims to avoid overtreatment of patients with an indolent lesion. The diagnosis of NIFTP has recently been revisi...

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Autores principales: Paniza, Ana Carolina de Jesus, Mendes, Thais Biude, Viana, Matheus Duarte Borges, Thomaz, Débora Mota Dias, Chiappini, Paula B O, Colozza-Gama, Gabriel A, Lindsey, Susan Chow, de Carvalho, Marcos Brasilino, Alves, Venâncio Avancini Ferreira, Curioni, Otavio, Bastos, André Uchimura, Cerutti, Janete Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893310/
https://www.ncbi.nlm.nih.gov/pubmed/31671409
http://dx.doi.org/10.1530/EC-19-0459
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author Paniza, Ana Carolina de Jesus
Mendes, Thais Biude
Viana, Matheus Duarte Borges
Thomaz, Débora Mota Dias
Chiappini, Paula B O
Colozza-Gama, Gabriel A
Lindsey, Susan Chow
de Carvalho, Marcos Brasilino
Alves, Venâncio Avancini Ferreira
Curioni, Otavio
Bastos, André Uchimura
Cerutti, Janete Maria
author_facet Paniza, Ana Carolina de Jesus
Mendes, Thais Biude
Viana, Matheus Duarte Borges
Thomaz, Débora Mota Dias
Chiappini, Paula B O
Colozza-Gama, Gabriel A
Lindsey, Susan Chow
de Carvalho, Marcos Brasilino
Alves, Venâncio Avancini Ferreira
Curioni, Otavio
Bastos, André Uchimura
Cerutti, Janete Maria
author_sort Paniza, Ana Carolina de Jesus
collection PubMed
description The recent reclassification of a follicular variant of papillary thyroid carcinoma (FVPTC), subset as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), aims to avoid overtreatment of patients with an indolent lesion. The diagnosis of NIFTP has recently been revisited using more rigid criteria. This study presents histological and molecular findings and a long clinical follow-up of 94 FVPTC, 40 cases of follicular adenoma (FTA) and 22 cases of follicular carcinoma (FTC) that were classified before the advent of the NIFTP reclassification. All slides were reviewed using these rigid criteria and analysis of numerous sections of paraffin blocks and reclassified as 7 NIFTPs, 2 EFVPTCs, 29 infiltrative FVPTC (IFVPTCs), 57 invasive EFVPTC (I-EFVPTCs), 39 FTAs and 22 FTCs. Remarkably, EFVPTC and NIFTP patients were all free of disease at the end of follow-up and showed no BRAF mutation. Only one NIFTP sample harbored mutations, an NRAS Q61R. PAX8/PPARG fusion was found in I-EFVPTCs and FTC. Although additional studies are needed to identify a specific molecular profile to aid in the diagnosis of lesions with borderline morphological characteristics, we confirmed that the BRAF V600E mutation is an important tool to exclude the diagnosis of NIFTP. We also show that rigorous histopathological criteria should be strongly followed to avoid missing lesions in which more aggressive behavior is present, mainly via the analysis of capsule or vascular invasion and the presence of papillary structures.
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spelling pubmed-68933102019-12-10 Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior Paniza, Ana Carolina de Jesus Mendes, Thais Biude Viana, Matheus Duarte Borges Thomaz, Débora Mota Dias Chiappini, Paula B O Colozza-Gama, Gabriel A Lindsey, Susan Chow de Carvalho, Marcos Brasilino Alves, Venâncio Avancini Ferreira Curioni, Otavio Bastos, André Uchimura Cerutti, Janete Maria Endocr Connect Research The recent reclassification of a follicular variant of papillary thyroid carcinoma (FVPTC), subset as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), aims to avoid overtreatment of patients with an indolent lesion. The diagnosis of NIFTP has recently been revisited using more rigid criteria. This study presents histological and molecular findings and a long clinical follow-up of 94 FVPTC, 40 cases of follicular adenoma (FTA) and 22 cases of follicular carcinoma (FTC) that were classified before the advent of the NIFTP reclassification. All slides were reviewed using these rigid criteria and analysis of numerous sections of paraffin blocks and reclassified as 7 NIFTPs, 2 EFVPTCs, 29 infiltrative FVPTC (IFVPTCs), 57 invasive EFVPTC (I-EFVPTCs), 39 FTAs and 22 FTCs. Remarkably, EFVPTC and NIFTP patients were all free of disease at the end of follow-up and showed no BRAF mutation. Only one NIFTP sample harbored mutations, an NRAS Q61R. PAX8/PPARG fusion was found in I-EFVPTCs and FTC. Although additional studies are needed to identify a specific molecular profile to aid in the diagnosis of lesions with borderline morphological characteristics, we confirmed that the BRAF V600E mutation is an important tool to exclude the diagnosis of NIFTP. We also show that rigorous histopathological criteria should be strongly followed to avoid missing lesions in which more aggressive behavior is present, mainly via the analysis of capsule or vascular invasion and the presence of papillary structures. Bioscientifica Ltd 2019-10-31 /pmc/articles/PMC6893310/ /pubmed/31671409 http://dx.doi.org/10.1530/EC-19-0459 Text en © 2019 The authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Research
Paniza, Ana Carolina de Jesus
Mendes, Thais Biude
Viana, Matheus Duarte Borges
Thomaz, Débora Mota Dias
Chiappini, Paula B O
Colozza-Gama, Gabriel A
Lindsey, Susan Chow
de Carvalho, Marcos Brasilino
Alves, Venâncio Avancini Ferreira
Curioni, Otavio
Bastos, André Uchimura
Cerutti, Janete Maria
Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior
title Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior
title_full Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior
title_fullStr Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior
title_full_unstemmed Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior
title_short Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior
title_sort revised criteria for diagnosis of niftp reveals a better correlation with tumor biological behavior
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893310/
https://www.ncbi.nlm.nih.gov/pubmed/31671409
http://dx.doi.org/10.1530/EC-19-0459
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