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Escaping the immune system by DNA repair and recombination in African trypanosomes
African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893398/ https://www.ncbi.nlm.nih.gov/pubmed/31718509 http://dx.doi.org/10.1098/rsob.190182 |
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author | Sima, Núria McLaughlin, Emilia Jane Hutchinson, Sebastian Glover, Lucy |
author_facet | Sima, Núria McLaughlin, Emilia Jane Hutchinson, Sebastian Glover, Lucy |
author_sort | Sima, Núria |
collection | PubMed |
description | African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed at a time from a specialized locus, known as an expression site. VSG switching is a predominantly recombination-driven process that allows VSG sequences to be recombined into the active expression site either replacing the currently active VSG or generating a ‘new’ VSG by segmental gene conversion. In this review, we describe what is known about the factors that influence this process, focusing specifically on DNA repair and recombination. |
format | Online Article Text |
id | pubmed-6893398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-68933982019-12-06 Escaping the immune system by DNA repair and recombination in African trypanosomes Sima, Núria McLaughlin, Emilia Jane Hutchinson, Sebastian Glover, Lucy Open Biol Review African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed at a time from a specialized locus, known as an expression site. VSG switching is a predominantly recombination-driven process that allows VSG sequences to be recombined into the active expression site either replacing the currently active VSG or generating a ‘new’ VSG by segmental gene conversion. In this review, we describe what is known about the factors that influence this process, focusing specifically on DNA repair and recombination. The Royal Society 2019-11-13 /pmc/articles/PMC6893398/ /pubmed/31718509 http://dx.doi.org/10.1098/rsob.190182 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Sima, Núria McLaughlin, Emilia Jane Hutchinson, Sebastian Glover, Lucy Escaping the immune system by DNA repair and recombination in African trypanosomes |
title | Escaping the immune system by DNA repair and recombination in African trypanosomes |
title_full | Escaping the immune system by DNA repair and recombination in African trypanosomes |
title_fullStr | Escaping the immune system by DNA repair and recombination in African trypanosomes |
title_full_unstemmed | Escaping the immune system by DNA repair and recombination in African trypanosomes |
title_short | Escaping the immune system by DNA repair and recombination in African trypanosomes |
title_sort | escaping the immune system by dna repair and recombination in african trypanosomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893398/ https://www.ncbi.nlm.nih.gov/pubmed/31718509 http://dx.doi.org/10.1098/rsob.190182 |
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