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Escaping the immune system by DNA repair and recombination in African trypanosomes

African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed a...

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Detalles Bibliográficos
Autores principales: Sima, Núria, McLaughlin, Emilia Jane, Hutchinson, Sebastian, Glover, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893398/
https://www.ncbi.nlm.nih.gov/pubmed/31718509
http://dx.doi.org/10.1098/rsob.190182
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author Sima, Núria
McLaughlin, Emilia Jane
Hutchinson, Sebastian
Glover, Lucy
author_facet Sima, Núria
McLaughlin, Emilia Jane
Hutchinson, Sebastian
Glover, Lucy
author_sort Sima, Núria
collection PubMed
description African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed at a time from a specialized locus, known as an expression site. VSG switching is a predominantly recombination-driven process that allows VSG sequences to be recombined into the active expression site either replacing the currently active VSG or generating a ‘new’ VSG by segmental gene conversion. In this review, we describe what is known about the factors that influence this process, focusing specifically on DNA repair and recombination.
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spelling pubmed-68933982019-12-06 Escaping the immune system by DNA repair and recombination in African trypanosomes Sima, Núria McLaughlin, Emilia Jane Hutchinson, Sebastian Glover, Lucy Open Biol Review African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed at a time from a specialized locus, known as an expression site. VSG switching is a predominantly recombination-driven process that allows VSG sequences to be recombined into the active expression site either replacing the currently active VSG or generating a ‘new’ VSG by segmental gene conversion. In this review, we describe what is known about the factors that influence this process, focusing specifically on DNA repair and recombination. The Royal Society 2019-11-13 /pmc/articles/PMC6893398/ /pubmed/31718509 http://dx.doi.org/10.1098/rsob.190182 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Sima, Núria
McLaughlin, Emilia Jane
Hutchinson, Sebastian
Glover, Lucy
Escaping the immune system by DNA repair and recombination in African trypanosomes
title Escaping the immune system by DNA repair and recombination in African trypanosomes
title_full Escaping the immune system by DNA repair and recombination in African trypanosomes
title_fullStr Escaping the immune system by DNA repair and recombination in African trypanosomes
title_full_unstemmed Escaping the immune system by DNA repair and recombination in African trypanosomes
title_short Escaping the immune system by DNA repair and recombination in African trypanosomes
title_sort escaping the immune system by dna repair and recombination in african trypanosomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893398/
https://www.ncbi.nlm.nih.gov/pubmed/31718509
http://dx.doi.org/10.1098/rsob.190182
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