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The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area

Background: Iodine supplementation during pregnancy in areas with mild-to-moderate iodine deficiency is still debated. Methods: A single-center, randomized, single-blind and placebo-controlled (3:2) trial was conducted. We enrolled 90 women before 12 weeks of gestation. From enrollment up until 8 we...

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Autores principales: Censi, Simona, Watutantrige-Fernando, Sara, Groccia, Giulia, Manso, Jacopo, Plebani, Mario, Faggian, Diego, Mion, Monica Maria, Venturini, Roberta, Andrisani, Alessandra, Casaro, Anna, Vita, Pietro, Avogadro, Alessandra, Camilot, Marta, Scaroni, Carla, Bertazza, Loris, Barollo, Susi, Mian, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893432/
https://www.ncbi.nlm.nih.gov/pubmed/31689890
http://dx.doi.org/10.3390/nu11112639
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author Censi, Simona
Watutantrige-Fernando, Sara
Groccia, Giulia
Manso, Jacopo
Plebani, Mario
Faggian, Diego
Mion, Monica Maria
Venturini, Roberta
Andrisani, Alessandra
Casaro, Anna
Vita, Pietro
Avogadro, Alessandra
Camilot, Marta
Scaroni, Carla
Bertazza, Loris
Barollo, Susi
Mian, Caterina
author_facet Censi, Simona
Watutantrige-Fernando, Sara
Groccia, Giulia
Manso, Jacopo
Plebani, Mario
Faggian, Diego
Mion, Monica Maria
Venturini, Roberta
Andrisani, Alessandra
Casaro, Anna
Vita, Pietro
Avogadro, Alessandra
Camilot, Marta
Scaroni, Carla
Bertazza, Loris
Barollo, Susi
Mian, Caterina
author_sort Censi, Simona
collection PubMed
description Background: Iodine supplementation during pregnancy in areas with mild-to-moderate iodine deficiency is still debated. Methods: A single-center, randomized, single-blind and placebo-controlled (3:2) trial was conducted. We enrolled 90 women before 12 weeks of gestation. From enrollment up until 8 weeks after delivery, 52 women were given an iodine supplement (225 ug/day, potassium iodide tablets) and 38 were given placebo. At recruitment (T0), in the second (T1) and third trimesters (T2), and 8 weeks after delivery (T3), we measured participants’ urinary iodine-to-creatinine ratio (UI/Creat), thyroid function parameters (thyroglobulin (Tg), TSH, FT3, and FT4), and thyroid volume (TV). The newborns’ urinary iodine concentrations were evaluated in 16 cases. Results: Median UI/Creat at recruitment was 53.3 ug/g. UI/Creat was significantly higher in supplemented women at T1 and T2. Tg levels were lower at T1 and T2 in women with UI/Creat ≥ 150 ug/g, and in the Iodine group at T2 (p = 0.02). There was a negative correlation between Tg and UI/Creat throughout the study (p = 0.03, r = −0.1268). A lower TSH level was found in the Iodine group at T3 (p = 0.001). TV increased by +Δ7.43% in the Iodine group, and by +Δ11.17% in the Placebo group. No differences were found between the newborns’ TSH levels on screening the two groups. Conclusion: Tg proved a good parameter for measuring iodine intake in our placebo-controlled series. Iodine supplementation did not prove harmful to pregnancy in areas of mild-to-moderate iodine deficiency, with no appreciable harmful effect on thyroid function.
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spelling pubmed-68934322019-12-23 The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area Censi, Simona Watutantrige-Fernando, Sara Groccia, Giulia Manso, Jacopo Plebani, Mario Faggian, Diego Mion, Monica Maria Venturini, Roberta Andrisani, Alessandra Casaro, Anna Vita, Pietro Avogadro, Alessandra Camilot, Marta Scaroni, Carla Bertazza, Loris Barollo, Susi Mian, Caterina Nutrients Article Background: Iodine supplementation during pregnancy in areas with mild-to-moderate iodine deficiency is still debated. Methods: A single-center, randomized, single-blind and placebo-controlled (3:2) trial was conducted. We enrolled 90 women before 12 weeks of gestation. From enrollment up until 8 weeks after delivery, 52 women were given an iodine supplement (225 ug/day, potassium iodide tablets) and 38 were given placebo. At recruitment (T0), in the second (T1) and third trimesters (T2), and 8 weeks after delivery (T3), we measured participants’ urinary iodine-to-creatinine ratio (UI/Creat), thyroid function parameters (thyroglobulin (Tg), TSH, FT3, and FT4), and thyroid volume (TV). The newborns’ urinary iodine concentrations were evaluated in 16 cases. Results: Median UI/Creat at recruitment was 53.3 ug/g. UI/Creat was significantly higher in supplemented women at T1 and T2. Tg levels were lower at T1 and T2 in women with UI/Creat ≥ 150 ug/g, and in the Iodine group at T2 (p = 0.02). There was a negative correlation between Tg and UI/Creat throughout the study (p = 0.03, r = −0.1268). A lower TSH level was found in the Iodine group at T3 (p = 0.001). TV increased by +Δ7.43% in the Iodine group, and by +Δ11.17% in the Placebo group. No differences were found between the newborns’ TSH levels on screening the two groups. Conclusion: Tg proved a good parameter for measuring iodine intake in our placebo-controlled series. Iodine supplementation did not prove harmful to pregnancy in areas of mild-to-moderate iodine deficiency, with no appreciable harmful effect on thyroid function. MDPI 2019-11-04 /pmc/articles/PMC6893432/ /pubmed/31689890 http://dx.doi.org/10.3390/nu11112639 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Censi, Simona
Watutantrige-Fernando, Sara
Groccia, Giulia
Manso, Jacopo
Plebani, Mario
Faggian, Diego
Mion, Monica Maria
Venturini, Roberta
Andrisani, Alessandra
Casaro, Anna
Vita, Pietro
Avogadro, Alessandra
Camilot, Marta
Scaroni, Carla
Bertazza, Loris
Barollo, Susi
Mian, Caterina
The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area
title The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area
title_full The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area
title_fullStr The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area
title_full_unstemmed The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area
title_short The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area
title_sort effects of iodine supplementation in pregnancy on iodine status, thyroglobulin levels and thyroid function parameters: results from a randomized controlled clinical trial in a mild-to-moderate iodine deficiency area
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893432/
https://www.ncbi.nlm.nih.gov/pubmed/31689890
http://dx.doi.org/10.3390/nu11112639
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