Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor

Triple negative breast cancers (TNBC) are the most aggressive and lethal breast cancers (BC). The aryl hydrocarbon receptor (AHR) is often overexpressed in TNBC, and its activation results in the epigenetic silencing of BRCA1, which is a necessary factor for the transcriptional activation of estroge...

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Detalles Bibliográficos
Autores principales: Donovan, Micah G., Selmin, Ornella I., Doetschman, Thomas C., Romagnolo, Donato F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893467/
https://www.ncbi.nlm.nih.gov/pubmed/31652854
http://dx.doi.org/10.3390/nu11112559

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