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Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model

Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet c...

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Autores principales: Cancelliere, Rosa, Leone, Serena, Gatto, Cristina, Mazzoli, Arianna, Ercole, Carmine, Iossa, Susanna, Liverini, Giovanna, Picone, Delia, Crescenzo, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893535/
https://www.ncbi.nlm.nih.gov/pubmed/31689911
http://dx.doi.org/10.3390/nu11112643
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author Cancelliere, Rosa
Leone, Serena
Gatto, Cristina
Mazzoli, Arianna
Ercole, Carmine
Iossa, Susanna
Liverini, Giovanna
Picone, Delia
Crescenzo, Raffaella
author_facet Cancelliere, Rosa
Leone, Serena
Gatto, Cristina
Mazzoli, Arianna
Ercole, Carmine
Iossa, Susanna
Liverini, Giovanna
Picone, Delia
Crescenzo, Raffaella
author_sort Cancelliere, Rosa
collection PubMed
description Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners, but their introduction on the food market has been delayed by some factors, among which is the lack of thorough metabolic and toxicological studies. We have tried to shed light on the potential of a sweet protein, MNEI, as a fructose substitute in beverages in a typical western diet, by studying the metabolic consequences of its consumption on a Wistar rat model of high fat diet-induced obesity. In particular, we investigated the lipid profile, insulin sensitivity and other indicators of metabolic syndrome. We also evaluated systemic inflammation and potential colon damage. MNEI consumption rescued the metabolic derangement elicited by the intake of fructose, namely insulin resistance, altered plasma lipid profile, colon inflammation and translocation of lipopolysaccharides from the gut lumen into the circulatory system. We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.
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spelling pubmed-68935352019-12-23 Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model Cancelliere, Rosa Leone, Serena Gatto, Cristina Mazzoli, Arianna Ercole, Carmine Iossa, Susanna Liverini, Giovanna Picone, Delia Crescenzo, Raffaella Nutrients Article Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners, but their introduction on the food market has been delayed by some factors, among which is the lack of thorough metabolic and toxicological studies. We have tried to shed light on the potential of a sweet protein, MNEI, as a fructose substitute in beverages in a typical western diet, by studying the metabolic consequences of its consumption on a Wistar rat model of high fat diet-induced obesity. In particular, we investigated the lipid profile, insulin sensitivity and other indicators of metabolic syndrome. We also evaluated systemic inflammation and potential colon damage. MNEI consumption rescued the metabolic derangement elicited by the intake of fructose, namely insulin resistance, altered plasma lipid profile, colon inflammation and translocation of lipopolysaccharides from the gut lumen into the circulatory system. We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present. MDPI 2019-11-04 /pmc/articles/PMC6893535/ /pubmed/31689911 http://dx.doi.org/10.3390/nu11112643 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cancelliere, Rosa
Leone, Serena
Gatto, Cristina
Mazzoli, Arianna
Ercole, Carmine
Iossa, Susanna
Liverini, Giovanna
Picone, Delia
Crescenzo, Raffaella
Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
title Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
title_full Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
title_fullStr Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
title_full_unstemmed Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
title_short Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
title_sort metabolic effects of the sweet protein mnei as a sweetener in drinking water. a pilot study of a high fat dietary regimen in a rodent model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893535/
https://www.ncbi.nlm.nih.gov/pubmed/31689911
http://dx.doi.org/10.3390/nu11112643
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