Cargando…
Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model
Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet c...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893535/ https://www.ncbi.nlm.nih.gov/pubmed/31689911 http://dx.doi.org/10.3390/nu11112643 |
_version_ | 1783476219954593792 |
---|---|
author | Cancelliere, Rosa Leone, Serena Gatto, Cristina Mazzoli, Arianna Ercole, Carmine Iossa, Susanna Liverini, Giovanna Picone, Delia Crescenzo, Raffaella |
author_facet | Cancelliere, Rosa Leone, Serena Gatto, Cristina Mazzoli, Arianna Ercole, Carmine Iossa, Susanna Liverini, Giovanna Picone, Delia Crescenzo, Raffaella |
author_sort | Cancelliere, Rosa |
collection | PubMed |
description | Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners, but their introduction on the food market has been delayed by some factors, among which is the lack of thorough metabolic and toxicological studies. We have tried to shed light on the potential of a sweet protein, MNEI, as a fructose substitute in beverages in a typical western diet, by studying the metabolic consequences of its consumption on a Wistar rat model of high fat diet-induced obesity. In particular, we investigated the lipid profile, insulin sensitivity and other indicators of metabolic syndrome. We also evaluated systemic inflammation and potential colon damage. MNEI consumption rescued the metabolic derangement elicited by the intake of fructose, namely insulin resistance, altered plasma lipid profile, colon inflammation and translocation of lipopolysaccharides from the gut lumen into the circulatory system. We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present. |
format | Online Article Text |
id | pubmed-6893535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68935352019-12-23 Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model Cancelliere, Rosa Leone, Serena Gatto, Cristina Mazzoli, Arianna Ercole, Carmine Iossa, Susanna Liverini, Giovanna Picone, Delia Crescenzo, Raffaella Nutrients Article Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners, but their introduction on the food market has been delayed by some factors, among which is the lack of thorough metabolic and toxicological studies. We have tried to shed light on the potential of a sweet protein, MNEI, as a fructose substitute in beverages in a typical western diet, by studying the metabolic consequences of its consumption on a Wistar rat model of high fat diet-induced obesity. In particular, we investigated the lipid profile, insulin sensitivity and other indicators of metabolic syndrome. We also evaluated systemic inflammation and potential colon damage. MNEI consumption rescued the metabolic derangement elicited by the intake of fructose, namely insulin resistance, altered plasma lipid profile, colon inflammation and translocation of lipopolysaccharides from the gut lumen into the circulatory system. We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present. MDPI 2019-11-04 /pmc/articles/PMC6893535/ /pubmed/31689911 http://dx.doi.org/10.3390/nu11112643 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cancelliere, Rosa Leone, Serena Gatto, Cristina Mazzoli, Arianna Ercole, Carmine Iossa, Susanna Liverini, Giovanna Picone, Delia Crescenzo, Raffaella Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model |
title | Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model |
title_full | Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model |
title_fullStr | Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model |
title_full_unstemmed | Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model |
title_short | Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model |
title_sort | metabolic effects of the sweet protein mnei as a sweetener in drinking water. a pilot study of a high fat dietary regimen in a rodent model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893535/ https://www.ncbi.nlm.nih.gov/pubmed/31689911 http://dx.doi.org/10.3390/nu11112643 |
work_keys_str_mv | AT cancelliererosa metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT leoneserena metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT gattocristina metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT mazzoliarianna metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT ercolecarmine metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT iossasusanna metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT liverinigiovanna metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT piconedelia metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel AT crescenzoraffaella metaboliceffectsofthesweetproteinmneiasasweetenerindrinkingwaterapilotstudyofahighfatdietaryregimeninarodentmodel |