Cargando…

Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects

Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating polymorphisms in candidate genes have been inconsistent, and, in addition, very f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ortega-Azorín, Carolina, Coltell, Oscar, Asensio, Eva M., Sorlí, Jose V., González, José I., Portolés, Olga, Saiz, Carmen, Estruch, Ramon, Ramírez-Sabio, Judith B, Pérez-Fidalgo, Alejandro, Ordovas, Jose M, Corella, Dolores
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893551/ https://www.ncbi.nlm.nih.gov/pubmed/31766143 http://dx.doi.org/10.3390/nu11112751

Ejemplares similares

Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects
por: Coltell, Oscar, et al.
Publicado: (2021)

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk
por: Sorlí, Jose V., et al.
Publicado: (2020)

Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk
por: Coltell, Oscar, et al.
Publicado: (2023)

MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
por: Barragán, Rocío, et al.
Publicado: (2016)

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome
por: Coltell, Oscar, et al.
Publicado: (2020)

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
por: Barragán, Rocio, et al.
Publicado: (2018)

DNA-Methylation Signatures of Tobacco Smoking in a High Cardiovascular Risk Population: Modulation by the Mediterranean Diet
por: Fernández-Carrión, Rebeca, et al.
Publicado: (2023)

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population
por: Barragán, Rocío, et al.
Publicado: (2020)

Association between the APOA2 promoter polymorphism and body-weight in Mediterranean and Asian populations. Replication of a gene-saturated fat interaction
por: Corella, Dolores, et al.
Publicado: (2010)

A Transcriptome-Wide Association Study of Cognitive Impairment in Subjects With Metabolic Syndrome Adjusted for Adherence to Mediterranean Diet
por: Coltell, Oscar, et al.
Publicado: (2022)

Association between Adherence to a Mediterranean Diet Pattern and DNA Methylation of the Main Autophagy-Related Genes
por: Corella, Dolores, et al.
Publicado: (2022)

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population
por: Barragán, Rocío, et al.
Publicado: (2022)

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
por: Coltell, Oscar, et al.
Publicado: (2019)

Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies
por: Barragán, Rocío, et al.
Publicado: (2021)

A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations
por: Zanon-Moreno, Vicente, et al.
Publicado: (2017)

Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
por: Asensio, Eva M., et al.
Publicado: (2022)

Influence of DNA-Polymorphisms in Selected Circadian Clock Genes on Clock Gene Expression in Subjects from the General Population and Their Association with Sleep Duration
por: Barragán, Rocío, et al.
Publicado: (2022)

Associations between Taste Perception Profiles and Empirically Derived Dietary Patterns: An Exploratory Analysis among Older Adults with Metabolic Syndrome
por: Gervis, Julie E., et al.
Publicado: (2021)

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
por: Ortega-Azorín, Carolina, et al.
Publicado: (2012)

A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
por: Corella, Dolores, et al.
Publicado: (2018)

Timing of Meals and Sleep in the Mediterranean Population: The Effect of Taste, Genetics, Environmental Determinants, and Interactions on Obesity Phenotypes
por: Barragán, Rocío, et al.
Publicado: (2023)

Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome
por: Fernández-Carrión, Rebeca, et al.
Publicado: (2021)

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
por: Corella, Dolores, et al.
Publicado: (2016)

Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover Study
por: Lacalle-Bergeron, Leticia, et al.
Publicado: (2020)

Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
por: Corella, Dolores, et al.
Publicado: (2014)

Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in a high-cardiovascular-risk population
por: Corella, Dolores, et al.
Publicado: (2013)

Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization
por: Smith, Caren E., et al.
Publicado: (2016)

Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores
por: Corella, Dolores, et al.
Publicado: (2016)

Statistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption
por: Corella, Dolores, et al.
Publicado: (2012)

Effects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucoma
por: Zanon-Moreno, Vicente, et al.
Publicado: (2013)

Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children
por: Viljakainen, Heli, et al.
Publicado: (2023)

Lifestyles and Risk Factors Associated with Adherence to the Mediterranean Diet: A Baseline Assessment of the PREDIMED Trial
por: Hu, Emily A., et al.
Publicado: (2013)

The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery
por: García-Layana, Alfredo, et al.
Publicado: (2017)

Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population
por: Zanon-Moreno, Vicente, et al.
Publicado: (2011)

Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus
por: Almanza-Aguilera, Enrique, et al.
Publicado: (2020)

Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
por: Casas, Rosa, et al.
Publicado: (2017)

Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial
por: Martínez-González, Miguel A., et al.
Publicado: (2023)

Mediterranean Diet and White Blood Cell Count—A Randomized Controlled Trial
por: Hernáez, Álvaro, et al.
Publicado: (2021)

Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial
por: Toledo, Estefania, et al.
Publicado: (2013)

Predictors of short- and long-term adherence with a Mediterranean-type diet intervention: the PREDIMED randomized trial
por: Downer, Mary Kathryn, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pr9tv8vvr9lnh5uajn2628j37s