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Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

The eight mammalian Src-family tyrosine kinases are dynamic, multi-domain structures, which adopt distinct “open” and “closed” conformations. In the closed conformation, the regulatory SH3 and SH2 domains pack against the back of the kinase domain, providing allosteric control of kinase activity. Sm...

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Detalles Bibliográficos
Autores principales:	Dorman, Heather R., Close, David, Wingert, Bentley M., Camacho, Carlos J., Johnston, Paul A., Smithgall, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893557/ https://www.ncbi.nlm.nih.gov/pubmed/31850311 http://dx.doi.org/10.3389/fchem.2019.00822

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