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The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, includ...

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Autores principales: Ghanem, Paola, Zouein, Annalise, Mohamad, Maya, Hodroj, Mohammad H., Haykal, Tony, Abou Najem, Sonia, Naim, Hassan Y., Rizk, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893610/
https://www.ncbi.nlm.nih.gov/pubmed/31744219
http://dx.doi.org/10.3390/nu11112808
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author Ghanem, Paola
Zouein, Annalise
Mohamad, Maya
Hodroj, Mohammad H.
Haykal, Tony
Abou Najem, Sonia
Naim, Hassan Y.
Rizk, Sandra
author_facet Ghanem, Paola
Zouein, Annalise
Mohamad, Maya
Hodroj, Mohammad H.
Haykal, Tony
Abou Najem, Sonia
Naim, Hassan Y.
Rizk, Sandra
author_sort Ghanem, Paola
collection PubMed
description Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.
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spelling pubmed-68936102019-12-23 The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines Ghanem, Paola Zouein, Annalise Mohamad, Maya Hodroj, Mohammad H. Haykal, Tony Abou Najem, Sonia Naim, Hassan Y. Rizk, Sandra Nutrients Article Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway. MDPI 2019-11-17 /pmc/articles/PMC6893610/ /pubmed/31744219 http://dx.doi.org/10.3390/nu11112808 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ghanem, Paola
Zouein, Annalise
Mohamad, Maya
Hodroj, Mohammad H.
Haykal, Tony
Abou Najem, Sonia
Naim, Hassan Y.
Rizk, Sandra
The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_full The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_fullStr The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_full_unstemmed The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_short The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_sort vitamin e derivative gamma tocotrienol promotes anti-tumor effects in acute myeloid leukemia cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893610/
https://www.ncbi.nlm.nih.gov/pubmed/31744219
http://dx.doi.org/10.3390/nu11112808
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