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Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women
Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women afte...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893628/ https://www.ncbi.nlm.nih.gov/pubmed/31689902 http://dx.doi.org/10.3390/nu11112641 |
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author | Reyes-Garcia, Rebeca Garcia-Martin, Antonia Palacios, Santiago Salas, Nancy Mendoza, Nicolas Quesada-Charneco, Miguel Fonolla, Juristo Lara-Villoslada, Federico Muñoz-Torres, Manuel |
author_facet | Reyes-Garcia, Rebeca Garcia-Martin, Antonia Palacios, Santiago Salas, Nancy Mendoza, Nicolas Quesada-Charneco, Miguel Fonolla, Juristo Lara-Villoslada, Federico Muñoz-Torres, Manuel |
author_sort | Reyes-Garcia, Rebeca |
collection | PubMed |
description | Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified with vitamin D and calcium. Methods: We designed a prospective study including 305 healthy postmenopausal women who consumed a fortified milk with calcium (900 mg/500 mL) and vitamin D3 (600 IU/500 mL) daily for 24 months. Results: The 25(OH)D concentrations at 24 months were correlated to weight, to body mass index, to the percentage of fat, triglycerides and to baseline 25(OH)D levels. We found significant differences in the levels of 25(OH)D at 24 months according to baseline 25(OH)D levels (p < 0.001) and body mass index (p = 0.019) expressed at quartiles. Multivariate analysis showed an association between levels of 25(OH)D after the intervention and at baseline 25(OH)D (Beta = 0.47, p < 0.001) and percentage of body fat (Beta = −0.227, p = 0.049), regardless of the body mass index. Conclusions: In healthy postmenopausal women, the improvement in 25(OH)D after an intervention with a fortified milk for 24 months depends mainly on the baseline levels of serum 25(OH)D and on the percentage of body fat. |
format | Online Article Text |
id | pubmed-6893628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68936282019-12-23 Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women Reyes-Garcia, Rebeca Garcia-Martin, Antonia Palacios, Santiago Salas, Nancy Mendoza, Nicolas Quesada-Charneco, Miguel Fonolla, Juristo Lara-Villoslada, Federico Muñoz-Torres, Manuel Nutrients Article Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified with vitamin D and calcium. Methods: We designed a prospective study including 305 healthy postmenopausal women who consumed a fortified milk with calcium (900 mg/500 mL) and vitamin D3 (600 IU/500 mL) daily for 24 months. Results: The 25(OH)D concentrations at 24 months were correlated to weight, to body mass index, to the percentage of fat, triglycerides and to baseline 25(OH)D levels. We found significant differences in the levels of 25(OH)D at 24 months according to baseline 25(OH)D levels (p < 0.001) and body mass index (p = 0.019) expressed at quartiles. Multivariate analysis showed an association between levels of 25(OH)D after the intervention and at baseline 25(OH)D (Beta = 0.47, p < 0.001) and percentage of body fat (Beta = −0.227, p = 0.049), regardless of the body mass index. Conclusions: In healthy postmenopausal women, the improvement in 25(OH)D after an intervention with a fortified milk for 24 months depends mainly on the baseline levels of serum 25(OH)D and on the percentage of body fat. MDPI 2019-11-04 /pmc/articles/PMC6893628/ /pubmed/31689902 http://dx.doi.org/10.3390/nu11112641 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Reyes-Garcia, Rebeca Garcia-Martin, Antonia Palacios, Santiago Salas, Nancy Mendoza, Nicolas Quesada-Charneco, Miguel Fonolla, Juristo Lara-Villoslada, Federico Muñoz-Torres, Manuel Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women |
title | Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women |
title_full | Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women |
title_fullStr | Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women |
title_full_unstemmed | Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women |
title_short | Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women |
title_sort | factors predicting the response to a vitamin d-fortified milk in healthy postmenopausal women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893628/ https://www.ncbi.nlm.nih.gov/pubmed/31689902 http://dx.doi.org/10.3390/nu11112641 |
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