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A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats
The antiepileptic effect of ketogenic diets is acknowledged but its mechanism of action is poorly understood. The present work aimed to evaluate possible effects of a calorie-restricted ketogenic diet (CRKD) on brain growth and angiogenesis in normal prepubertal rats. Two groups of prepubertal rats...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893715/ https://www.ncbi.nlm.nih.gov/pubmed/31694345 http://dx.doi.org/10.3390/nu11112681 |
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author | Viggiano, Andrea Meccariello, Rosaria Santoro, Antonietta Secondulfo, Carmine Operto, Francesca Felicia Monda, Marcellino Coppola, Giangennaro |
author_facet | Viggiano, Andrea Meccariello, Rosaria Santoro, Antonietta Secondulfo, Carmine Operto, Francesca Felicia Monda, Marcellino Coppola, Giangennaro |
author_sort | Viggiano, Andrea |
collection | PubMed |
description | The antiepileptic effect of ketogenic diets is acknowledged but its mechanism of action is poorly understood. The present work aimed to evaluate possible effects of a calorie-restricted ketogenic diet (CRKD) on brain growth and angiogenesis in normal prepubertal rats. Two groups of prepubertal rats were fed with a standard diet (group 1) or a CRKD (group 2) for ten weeks. Then, rats were sacrificed and the thickness for the following structures was evaluated by histology: (1) cerebral cortex, (2) deep cerebral white matter, and (3) substantia nigra. The capillary density was also evaluated within: (1) cerebral cortex, (2) dentate gyrus of the hippocampus, (3) periaqueductal grey matter, and (4) substantia nigra. The results showed a smaller thickness of all the areas examined and a reduced capillary density within the cerebral cortex in the CRKD-treated group compared to the control group. These findings suggest an association between reduced angiogenesis within the cerebral cortex and the antiepileptic effects of CRKD. |
format | Online Article Text |
id | pubmed-6893715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68937152019-12-23 A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats Viggiano, Andrea Meccariello, Rosaria Santoro, Antonietta Secondulfo, Carmine Operto, Francesca Felicia Monda, Marcellino Coppola, Giangennaro Nutrients Article The antiepileptic effect of ketogenic diets is acknowledged but its mechanism of action is poorly understood. The present work aimed to evaluate possible effects of a calorie-restricted ketogenic diet (CRKD) on brain growth and angiogenesis in normal prepubertal rats. Two groups of prepubertal rats were fed with a standard diet (group 1) or a CRKD (group 2) for ten weeks. Then, rats were sacrificed and the thickness for the following structures was evaluated by histology: (1) cerebral cortex, (2) deep cerebral white matter, and (3) substantia nigra. The capillary density was also evaluated within: (1) cerebral cortex, (2) dentate gyrus of the hippocampus, (3) periaqueductal grey matter, and (4) substantia nigra. The results showed a smaller thickness of all the areas examined and a reduced capillary density within the cerebral cortex in the CRKD-treated group compared to the control group. These findings suggest an association between reduced angiogenesis within the cerebral cortex and the antiepileptic effects of CRKD. MDPI 2019-11-05 /pmc/articles/PMC6893715/ /pubmed/31694345 http://dx.doi.org/10.3390/nu11112681 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Viggiano, Andrea Meccariello, Rosaria Santoro, Antonietta Secondulfo, Carmine Operto, Francesca Felicia Monda, Marcellino Coppola, Giangennaro A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats |
title | A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats |
title_full | A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats |
title_fullStr | A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats |
title_full_unstemmed | A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats |
title_short | A Calorie-Restricted Ketogenic Diet Reduces Cerebral Cortex Vascularization in Prepubertal Rats |
title_sort | calorie-restricted ketogenic diet reduces cerebral cortex vascularization in prepubertal rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893715/ https://www.ncbi.nlm.nih.gov/pubmed/31694345 http://dx.doi.org/10.3390/nu11112681 |
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