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Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial

Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of...

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Autores principales: Ruggiero, Carmelinda, Baroni, Marta, Bini, Vittorio, Brozzetti, Annalisa, Parretti, Luca, Zengarini, Elisa, Lapenna, Maria, Antinolfi, Pierluigi, Falorni, Alberto, Mecocci, Patrizia, Boccardi, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893743/
https://www.ncbi.nlm.nih.gov/pubmed/31731651
http://dx.doi.org/10.3390/nu11112778
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author Ruggiero, Carmelinda
Baroni, Marta
Bini, Vittorio
Brozzetti, Annalisa
Parretti, Luca
Zengarini, Elisa
Lapenna, Maria
Antinolfi, Pierluigi
Falorni, Alberto
Mecocci, Patrizia
Boccardi, Virginia
author_facet Ruggiero, Carmelinda
Baroni, Marta
Bini, Vittorio
Brozzetti, Annalisa
Parretti, Luca
Zengarini, Elisa
Lapenna, Maria
Antinolfi, Pierluigi
Falorni, Alberto
Mecocci, Patrizia
Boccardi, Virginia
author_sort Ruggiero, Carmelinda
collection PubMed
description Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment. Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01). Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04). Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites. In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.
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spelling pubmed-68937432019-12-23 Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial Ruggiero, Carmelinda Baroni, Marta Bini, Vittorio Brozzetti, Annalisa Parretti, Luca Zengarini, Elisa Lapenna, Maria Antinolfi, Pierluigi Falorni, Alberto Mecocci, Patrizia Boccardi, Virginia Nutrients Article Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment. Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01). Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04). Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites. In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels. MDPI 2019-11-15 /pmc/articles/PMC6893743/ /pubmed/31731651 http://dx.doi.org/10.3390/nu11112778 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruggiero, Carmelinda
Baroni, Marta
Bini, Vittorio
Brozzetti, Annalisa
Parretti, Luca
Zengarini, Elisa
Lapenna, Maria
Antinolfi, Pierluigi
Falorni, Alberto
Mecocci, Patrizia
Boccardi, Virginia
Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
title Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
title_full Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
title_fullStr Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
title_full_unstemmed Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
title_short Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
title_sort effects of weekly supplementation of cholecalciferol and calcifediol among the oldest-old people: findings from a randomized pragmatic clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893743/
https://www.ncbi.nlm.nih.gov/pubmed/31731651
http://dx.doi.org/10.3390/nu11112778
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