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Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study

Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we reported that eggplant was rich in choline esters, including acetylcholine (ACh), and had an antihypertensive effect in spontaneously hyp...

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Autores principales: Nishimura, Mie, Suzuki, Miho, Takahashi, Ryuto, Yamaguchi, Shohei, Tsubaki, Kazufumi, Fujita, Tomoyuki, Nishihira, Jun, Nakamura, Kozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893753/
https://www.ncbi.nlm.nih.gov/pubmed/31744060
http://dx.doi.org/10.3390/nu11112797
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author Nishimura, Mie
Suzuki, Miho
Takahashi, Ryuto
Yamaguchi, Shohei
Tsubaki, Kazufumi
Fujita, Tomoyuki
Nishihira, Jun
Nakamura, Kozo
author_facet Nishimura, Mie
Suzuki, Miho
Takahashi, Ryuto
Yamaguchi, Shohei
Tsubaki, Kazufumi
Fujita, Tomoyuki
Nishihira, Jun
Nakamura, Kozo
author_sort Nishimura, Mie
collection PubMed
description Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we reported that eggplant was rich in choline esters, including acetylcholine (ACh), and had an antihypertensive effect in spontaneously hypertensive rats. Here, we evaluated the effects of a continuous intake of eggplant powder on blood pressure (BP), stress, and psychological state (PS) in 100 stressed participants with normal-high BP or grade 1 hypertension in a randomized, double-blind, placebo-controlled, parallel-group comparative study. The participants were randomly assigned to the eggplant or placebo group. Participants in the eggplant group ingested capsules containing eggplant powder (1.2 g/day; 2.3 mg of ACh/day) for 12 weeks, whereas participants in the placebo group ingested placebo capsules. The primary outcome assessed was hospital BP. Secondary outcomes were stress and PS. Eggplant powder intake significantly decreased the hospital diastolic blood pressure (DBP) at week 8 overall and in the normal-high BP group, and the systolic blood pressure (SBP) and DBP at week 12 overall and in the grade 1 hypertension group, compared to those of the placebo group. It also improved negative PSs at week 8 or 12 in the normal-high BP group. This is the first evidence of the BP- and PS-improving effects of eggplant intake in humans. The functional substance responsible for the effects was estimated to be eggplant-derived choline ester, namely ACh.
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spelling pubmed-68937532019-12-23 Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study Nishimura, Mie Suzuki, Miho Takahashi, Ryuto Yamaguchi, Shohei Tsubaki, Kazufumi Fujita, Tomoyuki Nishihira, Jun Nakamura, Kozo Nutrients Article Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we reported that eggplant was rich in choline esters, including acetylcholine (ACh), and had an antihypertensive effect in spontaneously hypertensive rats. Here, we evaluated the effects of a continuous intake of eggplant powder on blood pressure (BP), stress, and psychological state (PS) in 100 stressed participants with normal-high BP or grade 1 hypertension in a randomized, double-blind, placebo-controlled, parallel-group comparative study. The participants were randomly assigned to the eggplant or placebo group. Participants in the eggplant group ingested capsules containing eggplant powder (1.2 g/day; 2.3 mg of ACh/day) for 12 weeks, whereas participants in the placebo group ingested placebo capsules. The primary outcome assessed was hospital BP. Secondary outcomes were stress and PS. Eggplant powder intake significantly decreased the hospital diastolic blood pressure (DBP) at week 8 overall and in the normal-high BP group, and the systolic blood pressure (SBP) and DBP at week 12 overall and in the grade 1 hypertension group, compared to those of the placebo group. It also improved negative PSs at week 8 or 12 in the normal-high BP group. This is the first evidence of the BP- and PS-improving effects of eggplant intake in humans. The functional substance responsible for the effects was estimated to be eggplant-derived choline ester, namely ACh. MDPI 2019-11-16 /pmc/articles/PMC6893753/ /pubmed/31744060 http://dx.doi.org/10.3390/nu11112797 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishimura, Mie
Suzuki, Miho
Takahashi, Ryuto
Yamaguchi, Shohei
Tsubaki, Kazufumi
Fujita, Tomoyuki
Nishihira, Jun
Nakamura, Kozo
Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
title Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
title_full Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
title_fullStr Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
title_full_unstemmed Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
title_short Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
title_sort daily ingestion of eggplant powder improves blood pressure and psychological state in stressed individuals: a randomized placebo-controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893753/
https://www.ncbi.nlm.nih.gov/pubmed/31744060
http://dx.doi.org/10.3390/nu11112797
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