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The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects

A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal...

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Autores principales: Pham, Hung, Holen, Iselin S., Phillips, Liza K., Hatzinikolas, Seva, Huynh, Lian Q., Wu, Tongzhi, Hausken, Trygve, Rayner, Christopher K., Horowitz, Michael, Jones, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893806/
https://www.ncbi.nlm.nih.gov/pubmed/31694157
http://dx.doi.org/10.3390/nu11112666
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author Pham, Hung
Holen, Iselin S.
Phillips, Liza K.
Hatzinikolas, Seva
Huynh, Lian Q.
Wu, Tongzhi
Hausken, Trygve
Rayner, Christopher K.
Horowitz, Michael
Jones, Karen L.
author_facet Pham, Hung
Holen, Iselin S.
Phillips, Liza K.
Hatzinikolas, Seva
Huynh, Lian Q.
Wu, Tongzhi
Hausken, Trygve
Rayner, Christopher K.
Horowitz, Michael
Jones, Karen L.
author_sort Pham, Hung
collection PubMed
description A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal absorption. This preload also may be useful in the management of postprandial hypotension. We evaluated the effects of a whey protein/guar preload on gastric emptying, glucose absorption, glycaemic/insulinaemic and blood pressure (BP) responses to an oral glucose load. Eighteen healthy older participants underwent measurements of gastric emptying (scintigraphy), plasma glucose and insulin, glucose absorption, superior mesenteric artery (SMA) flow, BP and heart rate (HR) after ingesting a 50 g glucose drink, with or without the preload. The preload reduced plasma glucose (p = 0.02) and serum 3-O-methylglucose (3-OMG) (p = 0.003), and increased plasma insulin (p = 0.03). There was no difference in gastric emptying or BP between the two days. The reduction in plasma glucose on the preload day was related to the reduction in glucose absorption (r = 0.71, p = 0.002). In conclusion, the glucose-lowering effect of the preload may relate to delayed small intestinal glucose absorption and insulin stimulation, rather than slowing of gastric emptying.
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spelling pubmed-68938062019-12-23 The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects Pham, Hung Holen, Iselin S. Phillips, Liza K. Hatzinikolas, Seva Huynh, Lian Q. Wu, Tongzhi Hausken, Trygve Rayner, Christopher K. Horowitz, Michael Jones, Karen L. Nutrients Article A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal absorption. This preload also may be useful in the management of postprandial hypotension. We evaluated the effects of a whey protein/guar preload on gastric emptying, glucose absorption, glycaemic/insulinaemic and blood pressure (BP) responses to an oral glucose load. Eighteen healthy older participants underwent measurements of gastric emptying (scintigraphy), plasma glucose and insulin, glucose absorption, superior mesenteric artery (SMA) flow, BP and heart rate (HR) after ingesting a 50 g glucose drink, with or without the preload. The preload reduced plasma glucose (p = 0.02) and serum 3-O-methylglucose (3-OMG) (p = 0.003), and increased plasma insulin (p = 0.03). There was no difference in gastric emptying or BP between the two days. The reduction in plasma glucose on the preload day was related to the reduction in glucose absorption (r = 0.71, p = 0.002). In conclusion, the glucose-lowering effect of the preload may relate to delayed small intestinal glucose absorption and insulin stimulation, rather than slowing of gastric emptying. MDPI 2019-11-05 /pmc/articles/PMC6893806/ /pubmed/31694157 http://dx.doi.org/10.3390/nu11112666 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pham, Hung
Holen, Iselin S.
Phillips, Liza K.
Hatzinikolas, Seva
Huynh, Lian Q.
Wu, Tongzhi
Hausken, Trygve
Rayner, Christopher K.
Horowitz, Michael
Jones, Karen L.
The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects
title The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects
title_full The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects
title_fullStr The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects
title_full_unstemmed The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects
title_short The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects
title_sort effects of a whey protein and guar gum-containing preload on gastric emptying, glycaemia, small intestinal absorption and blood pressure in healthy older subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893806/
https://www.ncbi.nlm.nih.gov/pubmed/31694157
http://dx.doi.org/10.3390/nu11112666
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