Cargando…

Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals

Anomalous immune/inflammatory responses in obesity take place along with alterations in the neuroendocrine responses and dysregulation in the immune/stress feedback mechanisms. Exercise is a potential anti-inflammatory strategy in this context, but the influence of exercise on the β2 adrenergic regu...

Descripción completa

Detalles Bibliográficos
Autores principales: Gálvez, Isabel, Martín-Cordero, Leticia, Hinchado, María Dolores, Álvarez-Barrientos, Alberto, Ortega, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893831/
https://www.ncbi.nlm.nih.gov/pubmed/31684076
http://dx.doi.org/10.3390/nu11112630
_version_ 1783476291009249280
author Gálvez, Isabel
Martín-Cordero, Leticia
Hinchado, María Dolores
Álvarez-Barrientos, Alberto
Ortega, Eduardo
author_facet Gálvez, Isabel
Martín-Cordero, Leticia
Hinchado, María Dolores
Álvarez-Barrientos, Alberto
Ortega, Eduardo
author_sort Gálvez, Isabel
collection PubMed
description Anomalous immune/inflammatory responses in obesity take place along with alterations in the neuroendocrine responses and dysregulation in the immune/stress feedback mechanisms. Exercise is a potential anti-inflammatory strategy in this context, but the influence of exercise on the β2 adrenergic regulation of the monocyte-mediated inflammatory response in obesity remains completely unknown. The first objective of this study was to analyze the effect of exercise on the inflammatory profile and phenotype of monocytes from obese and lean animals, and the second aim was to determine whether obesity could affect monocytes’ inflammatory response to β2 adrenergic activation in exercised animals. C57BL/6J mice were allocated to different lean or obese groups: sedentary, with acute exercise, or with regular exercise. The inflammatory profile and phenotype of their circulating monocytes were evaluated by flow cytometry in the presence or absence of the selective β2 adrenergic receptor agonist terbutaline. Exercise caused an anti-inflammatory effect in obese individuals and a pro-inflammatory effect in lean individuals. β2 adrenergic receptor stimulation exerted a global pro-inflammatory effect in monocytes from exercised obese animals and an anti-inflammatory effect in monocytes from exercised lean animals. Thus, β2 adrenergic regulation of inflammation in monocytes from exercised animals seems to depend on the inflammatory basal set-point.
format Online
Article
Text
id pubmed-6893831
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-68938312019-12-23 Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals Gálvez, Isabel Martín-Cordero, Leticia Hinchado, María Dolores Álvarez-Barrientos, Alberto Ortega, Eduardo Nutrients Article Anomalous immune/inflammatory responses in obesity take place along with alterations in the neuroendocrine responses and dysregulation in the immune/stress feedback mechanisms. Exercise is a potential anti-inflammatory strategy in this context, but the influence of exercise on the β2 adrenergic regulation of the monocyte-mediated inflammatory response in obesity remains completely unknown. The first objective of this study was to analyze the effect of exercise on the inflammatory profile and phenotype of monocytes from obese and lean animals, and the second aim was to determine whether obesity could affect monocytes’ inflammatory response to β2 adrenergic activation in exercised animals. C57BL/6J mice were allocated to different lean or obese groups: sedentary, with acute exercise, or with regular exercise. The inflammatory profile and phenotype of their circulating monocytes were evaluated by flow cytometry in the presence or absence of the selective β2 adrenergic receptor agonist terbutaline. Exercise caused an anti-inflammatory effect in obese individuals and a pro-inflammatory effect in lean individuals. β2 adrenergic receptor stimulation exerted a global pro-inflammatory effect in monocytes from exercised obese animals and an anti-inflammatory effect in monocytes from exercised lean animals. Thus, β2 adrenergic regulation of inflammation in monocytes from exercised animals seems to depend on the inflammatory basal set-point. MDPI 2019-11-02 /pmc/articles/PMC6893831/ /pubmed/31684076 http://dx.doi.org/10.3390/nu11112630 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gálvez, Isabel
Martín-Cordero, Leticia
Hinchado, María Dolores
Álvarez-Barrientos, Alberto
Ortega, Eduardo
Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals
title Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals
title_full Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals
title_fullStr Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals
title_full_unstemmed Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals
title_short Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals
title_sort obesity affects β2 adrenergic regulation of the inflammatory profile and phenotype of circulating monocytes from exercised animals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893831/
https://www.ncbi.nlm.nih.gov/pubmed/31684076
http://dx.doi.org/10.3390/nu11112630
work_keys_str_mv AT galvezisabel obesityaffectsb2adrenergicregulationoftheinflammatoryprofileandphenotypeofcirculatingmonocytesfromexercisedanimals
AT martincorderoleticia obesityaffectsb2adrenergicregulationoftheinflammatoryprofileandphenotypeofcirculatingmonocytesfromexercisedanimals
AT hinchadomariadolores obesityaffectsb2adrenergicregulationoftheinflammatoryprofileandphenotypeofcirculatingmonocytesfromexercisedanimals
AT alvarezbarrientosalberto obesityaffectsb2adrenergicregulationoftheinflammatoryprofileandphenotypeofcirculatingmonocytesfromexercisedanimals
AT ortegaeduardo obesityaffectsb2adrenergicregulationoftheinflammatoryprofileandphenotypeofcirculatingmonocytesfromexercisedanimals