In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer

[Image: see text] The main aim of this study was to evaluate the in vitro and in vivo efficiency of the polyaspartic acid- and acrylic acid-based superabsorbent polymer. The synthesized polymer was first investigated to check the blood compatibility by protein adsorption and blood clotting tests. Fu...

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Autores principales: Sharma, Shilpa, Anwar, Mohammad Faiyaz, Dinda, Amit, Singhal, Maneesh, Malik, Amita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893953/
https://www.ncbi.nlm.nih.gov/pubmed/31815212
http://dx.doi.org/10.1021/acsomega.9b00655
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author Sharma, Shilpa
Anwar, Mohammad Faiyaz
Dinda, Amit
Singhal, Maneesh
Malik, Amita
author_facet Sharma, Shilpa
Anwar, Mohammad Faiyaz
Dinda, Amit
Singhal, Maneesh
Malik, Amita
author_sort Sharma, Shilpa
collection PubMed
description [Image: see text] The main aim of this study was to evaluate the in vitro and in vivo efficiency of the polyaspartic acid- and acrylic acid-based superabsorbent polymer. The synthesized polymer was first investigated to check the blood compatibility by protein adsorption and blood clotting tests. Further, the GHK-Cu peptide was incorporated within the polymer and release studies were performed to evaluate the drug-delivery efficiency of the superabsorbent polymer. The polymer with best peptide release results were further used for in vivo analysis for wound healing. The healing efficiency of polymer with and without peptide was analyzed using wound closure, biochemical assay, histopathological, and toxicity studies.
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spelling pubmed-68939532019-12-06 In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer Sharma, Shilpa Anwar, Mohammad Faiyaz Dinda, Amit Singhal, Maneesh Malik, Amita ACS Omega [Image: see text] The main aim of this study was to evaluate the in vitro and in vivo efficiency of the polyaspartic acid- and acrylic acid-based superabsorbent polymer. The synthesized polymer was first investigated to check the blood compatibility by protein adsorption and blood clotting tests. Further, the GHK-Cu peptide was incorporated within the polymer and release studies were performed to evaluate the drug-delivery efficiency of the superabsorbent polymer. The polymer with best peptide release results were further used for in vivo analysis for wound healing. The healing efficiency of polymer with and without peptide was analyzed using wound closure, biochemical assay, histopathological, and toxicity studies. American Chemical Society 2019-11-19 /pmc/articles/PMC6893953/ /pubmed/31815212 http://dx.doi.org/10.1021/acsomega.9b00655 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sharma, Shilpa
Anwar, Mohammad Faiyaz
Dinda, Amit
Singhal, Maneesh
Malik, Amita
In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer
title In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer
title_full In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer
title_fullStr In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer
title_full_unstemmed In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer
title_short In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer
title_sort in vitro and in vivo studies of ph-sensitive ghk-cu-incorporated polyaspartic and polyacrylic acid superabsorbent polymer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893953/
https://www.ncbi.nlm.nih.gov/pubmed/31815212
http://dx.doi.org/10.1021/acsomega.9b00655
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