Cargando…

ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer

BACKGROUND: Recent studies suggested that ZMYND10 is a potential tumor suppressor gene in multiple tumor types. However, the mechanism by which ZMYND10 inhibits breast cancer remains unclear. Here, we investigated the role and mechanism of ZMYND10 in breast cancer inhibition. RESULTS: ZMYND10 was dr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yan, Dan, Liangying, Li, Qianqian, Li, Lili, Zhong, Lan, Shao, Bianfei, Yu, Fang, He, Sanxiu, Tian, Shaorong, He, Jin, Xiao, Qian, Putti, Thomas C., He, Xiaoqian, Feng, Yixiao, Lin, Yong, Xiang, Tingxiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894283/ https://www.ncbi.nlm.nih.gov/pubmed/31801619 http://dx.doi.org/10.1186/s13148-019-0785-z

Ejemplares similares

Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer
por: Wang, Yan, et al.
Publicado: (2022)

Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin
por: Pu, Chunyun, et al.
Publicado: (2020)

Multiple targeted self-emulsifying compound RGO reveals obvious anti-tumor potential in hepatocellular carcinoma
por: He, Sanxiu, et al.
Publicado: (2021)

TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells
por: Fan, Jiangxia, et al.
Publicado: (2018)

DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis
por: Le, Xin, et al.
Publicado: (2020)

Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer
por: Xiang, Shili, et al.
Publicado: (2017)

Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis
por: Wu, Longji, et al.
Publicado: (2022)

Correction: Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis
por: Wu, Longji, et al.
Publicado: (2023)

The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer
por: Shao, Bianfei, et al.
Publicado: (2017)

KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer
por: Pei, Lijiao, et al.
Publicado: (2018)

Regulation of ZMYND8 to Treat Cancer
por: Chen, Yun, et al.
Publicado: (2021)

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling
por: Tao, Chunfang, et al.
Publicado: (2020)

Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer
por: Li, Shuman, et al.
Publicado: (2022)

Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer
por: Xiang, Qin, et al.
Publicado: (2023)

Mir 145/143: tumor suppressor, oncogenic microenvironmental factor or …both?
por: Cioce, Mario, et al.
Publicado: (2016)

Correction to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling
por: Tao, Chunfang, et al.
Publicado: (2022)

The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism
por: Feng, Yixiao, et al.
Publicado: (2018)

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells
por: Wang, Xue, et al.
Publicado: (2017)

NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma
por: Speranza, Maria Carmela, et al.
Publicado: (2012)

Protocadherin 17 functions as a tumor suppressor suppressing Wnt/β-catenin signaling and cell metastasis and is frequently methylated in breast cancer
por: Yin, Xuedong, et al.
Publicado: (2016)

ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms
por: Viaud, Manon, et al.
Publicado: (2020)

CircCDYL Acts as a Tumor Suppressor in Wilms’ Tumor by Targeting miR-145-5p
por: Zhou, Rui, et al.
Publicado: (2021)

Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma
por: Dong, Huiyue, et al.
Publicado: (2021)

Fusion of ZMYND8 and RELA Genes in Acute Erythroid Leukemia
por: Panagopoulos, Ioannis, et al.
Publicado: (2013)

Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization
por: Mukherjee, Shravanti, et al.
Publicado: (2020)

SETD2: an epigenetic modifier with tumor suppressor functionality
por: Li, Jun, et al.
Publicado: (2016)

Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation
por: Guzman, Frederick, et al.
Publicado: (2020)

The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest
por: Zhang, Yan, et al.
Publicado: (2018)

KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma
por: Zhang, Bo, et al.
Publicado: (2020)

Zinc-Finger Protein 545 Inhibits Cell Proliferation as a Tumor Suppressor through Inducing Apoptosis and is Disrupted by Promoter Methylation in Breast Cancer
por: Xiao, Yun, et al.
Publicado: (2014)

Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma
por: Mataki, Hiroko, et al.
Publicado: (2016)

ZMYND10 - Mutation Analysis in Slavic Patients with Primary Ciliary Dyskinesia
por: Kurkowiak, Małgorzata, et al.
Publicado: (2016)

SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells
por: Jiang, Yu, et al.
Publicado: (2020)

ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
por: Jia, Pan, et al.
Publicado: (2021)

Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p): inhibition of bladder cancer cell aggressiveness
por: Matsushita, Ryosuke, et al.
Publicado: (2016)

Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation
por: Bellissimo, Teresa, et al.
Publicado: (2017)

The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma
por: Foster, Jennifer H., et al.
Publicado: (2021)

Tumor suppressor activity of RIG-I
por: Li, Xian-Yang, et al.
Publicado: (2014)

VWCE Functions as a Tumor Suppressor in Breast Cancer Cells
por: Zhang, Dan, et al.
Publicado: (2020)

Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer
por: Kim, Seok-Jun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7hdk77okbmibfdidbj6hfn4abe