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Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis

BACKGROUND: Anemia is a common problem in HIV (human immunodeficiency virus) infected patients, and is associated with decreased functional capacity and quality of life. Ethiopia is one of the countries which has expanded highly active antiretroviral treatment (HAART) over the past years. The effect...

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Autores principales: Wagnew, Fasil, Eshetie, Setegn, Alebel, Animut, Tesema, Cheru, Kibret, Getiye Dejenu, Gebrie, Alemu, Dessie, Getenet, Abajobir, Amanuel Alemu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894299/
https://www.ncbi.nlm.nih.gov/pubmed/31801471
http://dx.doi.org/10.1186/s12879-019-4656-1
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author Wagnew, Fasil
Eshetie, Setegn
Alebel, Animut
Tesema, Cheru
Kibret, Getiye Dejenu
Gebrie, Alemu
Dessie, Getenet
Abajobir, Amanuel Alemu
author_facet Wagnew, Fasil
Eshetie, Setegn
Alebel, Animut
Tesema, Cheru
Kibret, Getiye Dejenu
Gebrie, Alemu
Dessie, Getenet
Abajobir, Amanuel Alemu
author_sort Wagnew, Fasil
collection PubMed
description BACKGROUND: Anemia is a common problem in HIV (human immunodeficiency virus) infected patients, and is associated with decreased functional capacity and quality of life. Ethiopia is one of the countries which has expanded highly active antiretroviral treatment (HAART) over the past years. The effect of HAART on anemia among HIV remains inconsistent and inconclusive, particularly in children. This study thus aimed to synthesize the prevalence of anemia among HIV infected Ethiopian children and its association with HAART initiation. METHODS: MEDLINE/PubMed, EMBASE, PsycINFO, Web of Science and Google scholar were used to identify 12 eligible studies reporting an association between anemia and HIV using a priori set criteria. PRISMA guideline was used to systematically review and meta-analysis these studies. Details of sample size, magnitude of effect sizes, including odds ratio (OR) and standard errors were extracted. Random-effects model was used to calculate the pooled estimates using STATA/SE version-14. I(2) and meta-bias statistics assessed heterogeneity and publication bias of the included studies. Sub-group analyses, based on study designs, were also carried out. RESULTS: In Ethiopia, the overall prevalence of anemia in HIV infected children was 22.3% (95% CI: 18.5–26.0%). The OR of anemia-HIV/AIDS comorbidity was 0.4 (95% CI, 0.2–0.5) in HAART initiated children as compared to non-initiated counterparts. Meta-bias and funnel plot detected no publication bias. CONCLUSION: On aggregate, anemia is a common comorbidity in pediatric HIV patients. HAART was significantly associated with a reduced anemia-HIV/AIDS comorbidity. Prompt start of HAART might help decreasing the prevalence of anemia and its subsequent complications.
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spelling pubmed-68942992019-12-11 Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis Wagnew, Fasil Eshetie, Setegn Alebel, Animut Tesema, Cheru Kibret, Getiye Dejenu Gebrie, Alemu Dessie, Getenet Abajobir, Amanuel Alemu BMC Infect Dis Research Article BACKGROUND: Anemia is a common problem in HIV (human immunodeficiency virus) infected patients, and is associated with decreased functional capacity and quality of life. Ethiopia is one of the countries which has expanded highly active antiretroviral treatment (HAART) over the past years. The effect of HAART on anemia among HIV remains inconsistent and inconclusive, particularly in children. This study thus aimed to synthesize the prevalence of anemia among HIV infected Ethiopian children and its association with HAART initiation. METHODS: MEDLINE/PubMed, EMBASE, PsycINFO, Web of Science and Google scholar were used to identify 12 eligible studies reporting an association between anemia and HIV using a priori set criteria. PRISMA guideline was used to systematically review and meta-analysis these studies. Details of sample size, magnitude of effect sizes, including odds ratio (OR) and standard errors were extracted. Random-effects model was used to calculate the pooled estimates using STATA/SE version-14. I(2) and meta-bias statistics assessed heterogeneity and publication bias of the included studies. Sub-group analyses, based on study designs, were also carried out. RESULTS: In Ethiopia, the overall prevalence of anemia in HIV infected children was 22.3% (95% CI: 18.5–26.0%). The OR of anemia-HIV/AIDS comorbidity was 0.4 (95% CI, 0.2–0.5) in HAART initiated children as compared to non-initiated counterparts. Meta-bias and funnel plot detected no publication bias. CONCLUSION: On aggregate, anemia is a common comorbidity in pediatric HIV patients. HAART was significantly associated with a reduced anemia-HIV/AIDS comorbidity. Prompt start of HAART might help decreasing the prevalence of anemia and its subsequent complications. BioMed Central 2019-12-04 /pmc/articles/PMC6894299/ /pubmed/31801471 http://dx.doi.org/10.1186/s12879-019-4656-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wagnew, Fasil
Eshetie, Setegn
Alebel, Animut
Tesema, Cheru
Kibret, Getiye Dejenu
Gebrie, Alemu
Dessie, Getenet
Abajobir, Amanuel Alemu
Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis
title Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis
title_full Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis
title_fullStr Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis
title_full_unstemmed Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis
title_short Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis
title_sort burden of anemia and its association with haart in hiv infected children in ethiopia: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894299/
https://www.ncbi.nlm.nih.gov/pubmed/31801471
http://dx.doi.org/10.1186/s12879-019-4656-1
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