Generation of targeted homozygosity in the genome of human induced pluripotent stem cells

When loss of heterozygosity (LOH) is correlated with loss or gain of a disease phenotype, it is often necessary to identify which gene or genes are involved. Here, we developed a region-specific LOH-inducing system based on mitotic crossover in human induced pluripotent stem cells (hiPSCs). We first...

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Detalles Bibliográficos
Autores principales: Yoshimura, Yasuhide, Yamanishi, Ayako, Kamitani, Tomo, Kim, Jin-Soo, Takeda, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894808/
https://www.ncbi.nlm.nih.gov/pubmed/31805151
http://dx.doi.org/10.1371/journal.pone.0225740

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