Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4(+)CD45RB(high) T cells

Amiselimod (MT-1303) is a novel sphingosine 1-phosphate receptor-1 (S1P(1) receptor) modulator with a more favorable cardiac safety profile than other S1P(1) receptor modulators. MT-1303 phosphate (MT-1303-P), an active metabolite of MT-1303, exhibits S1P(1) receptor agonism at a lower EC(50) value...

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Detalles Bibliográficos
Autores principales: Shimano, Kyoko, Maeda, Yasuhiro, Kataoka, Hirotoshi, Murase, Mikako, Mochizuki, Sachiko, Utsumi, Hiroyuki, Oshita, Koichi, Sugahara, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894856/
https://www.ncbi.nlm.nih.gov/pubmed/31805144
http://dx.doi.org/10.1371/journal.pone.0226154

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