IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway

Temozolomide (TMZ) is a first-line alkylating agent for glioblastoma multiforme (GBM). Clarifying the mechanisms inducing TMZ insensitivity may be helpful in improving its therapeutic effectiveness against GBM. Insulin-like growth factor (IGF)-1 signaling and micro (mi)RNAs are relevant in mediating...

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Detalles Bibliográficos
Autores principales: Chen, Ku-Chung, Chen, Peng-Hsu, Ho, Kuo-Hao, Shih, Chwen-Ming, Chou, Chih-Ming, Cheng, Chia-Hsiung, Lee, Chin-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894868/
https://www.ncbi.nlm.nih.gov/pubmed/31805126
http://dx.doi.org/10.1371/journal.pone.0225913

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