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Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations
PCSK9 is a protein secreted by the liver that binds to the low-density lipoprotein receptor (LDLR), causing LDLR internalization, decreasing the clearance of circulating LDL particles. Mutations in PCSK9 that strengthen its interactions with LDLR result in familial hypercholesterolemia (FH) and earl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894869/ https://www.ncbi.nlm.nih.gov/pubmed/31805108 http://dx.doi.org/10.1371/journal.pone.0225780 |